ArticleFrontiers in endocrinology2026
Limb salvage in diabetic foot necrotizing fasciitis complicated by extensively drug-resistant
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: When diabetic foot ulcers (DFUs) complicated by necrotizing fasciitis (NF) show persistent culture positivity for extensively drug-resistant Case presentation: A 59-year-old patient was admitted with a 20-day history of a right foot ulcer and a 10-year history of poorly controlled type 2 diabetes mellitus. The patient was initially diagnosed with diabetic foot ulcer, which progressed to lower-limb necrotizing fasciitis and septic shock requiring intensive care unit (ICU) supportive treatment. Due to persistent recovery of XDR-AB from wound cultures and severely limited effective systemic antibiotic options, the team used traditional Chinese medicine (TCM) as adjunctive therapy alongside standard debridement, vacuum sealing drainage (VSD), and intensive care support. Following the intervention, the patient's systemic inflammatory markers gradually stabilized despite persistent culture positivity, without recurrent sepsis. With the progressive clearance of necrotic tissue and the growth of healthy granulation tissue, the team successfully performed staged skin grafting while wound cultures remained positive on days 65 and 109, with complete graft take after both procedures. After 115 days of comprehensive treatment, the right lower limb wound stabilized, and the limb was successfully salvaged, allowing for a smooth discharge. Conclusion: For complex cases of DFUs complicated by NF and XDR-AB culture positivity where antibiotics are severely restricted, the addition of TCM to standard multidisciplinary care was associated with infection control and wound repair and may represent an exploratory limb-salvage approach. However, its generalizability and exact efficacy require further validation through subsequent research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.