Evidence map›Paper›PMID 42718558›Full record

ArticleFrontiers in cellular and infection microbiology2026

Isolation, characterization, and pathogenic mechanisms of a novel

Yibin Zhu, Ao Wang, Lianxiang Wang, Nanshan Qi, Haiming Cai, Dehong Yang, Ziying He, Shenquan Liao, Dongfang Zhao, Mingfei Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yibin ZhuWen's Group Academy, Wen's Foodstuffs Group Co., Ltd., Guangdong Provincial Enterprise Key Laboratory of Healthy Animal Husbandry and Environment Control Xinxing, Yunfu, China.
Ao WangWen's Group Academy, Wen's Foodstuffs Group Co., Ltd., Guangdong Provincial Enterprise Key Laboratory of Healthy Animal Husbandry and Environment Control Xinxing, Yunfu, China.
Lianxiang WangWen's Group Academy, Wen's Foodstuffs Group Co., Ltd., Guangdong Provincial Enterprise Key Laboratory of Healthy Animal Husbandry and Environment Control Xinxing, Yunfu, China.
Nanshan QiWen's Group Academy, Wen's Foodstuffs Group Co., Ltd., Guangdong Provincial Enterprise Key Laboratory of Healthy Animal Husbandry and Environment Control Xinxing, Yunfu, China.
Haiming CaiState Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Provincial Key Laboratory of Livestock Disease Prevention, Key Laboratory for prevention and control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou, China.
Dehong YangWen's Group Academy, Wen's Foodstuffs Group Co., Ltd., Guangdong Provincial Enterprise Key Laboratory of Healthy Animal Husbandry and Environment Control Xinxing, Yunfu, China.
Ziying HeWen's Group Academy, Wen's Foodstuffs Group Co., Ltd., Guangdong Provincial Enterprise Key Laboratory of Healthy Animal Husbandry and Environment Control Xinxing, Yunfu, China.
Shenquan LiaoWen's Group Academy, Wen's Foodstuffs Group Co., Ltd., Guangdong Provincial Enterprise Key Laboratory of Healthy Animal Husbandry and Environment Control Xinxing, Yunfu, China.
Dongfang ZhaoWen's Group Academy, Wen's Foodstuffs Group Co., Ltd., Guangdong Provincial Enterprise Key Laboratory of Healthy Animal Husbandry and Environment Control Xinxing, Yunfu, China.
Mingfei SunState Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Provincial Key Laboratory of Livestock Disease Prevention, Key Laboratory for prevention and control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: In this study, a novel Results: Phylogenetic analysis of the 16S rRNA gene confirmed its identity, and indirect immunofluorescence assay (IIFA) and scanning electron microscopy (SEM) demonstrated characteristic intracellular colonization and curved rod-shaped morphology. LIGD01 induced intermittent fecal shedding starting at 3 days post-infection (dpi), with seroconversion in all challenged pigs by 21 dpi. Necropsy revealed distinct ileal hyperplasia. Histopathology showed villous blunting, epithelial exfoliation, and inflammatory infiltration. Crucially, infection significantly reduced Average Daily Gain (ADG) (252.21 ± 17.07 g/day vs. 300.98 ± 19.39 g/day in controls, Discussion: This study not only provides a new candidate strain for vaccine development but also elucidates the physiological and microbial mechanisms underlying growth retardation in PPE.

Indexed as

Desulfovibrionaceae InfectionsEnteritisGastrointestinal MicrobiomeLawsonia BacteriaSwine DiseasesAnimalsChinaCytokinesDNA, BacterialDNA, RibosomalFecesIleumPhylogenyRNA, Ribosomal, 16SSequence Analysis, DNASwineCytokinesDNA, BacterialDNA, RibosomalRNA, Ribosomal, 16Sinfectionisolationlawsonia intracellularispathogenicityporcine proliferative enteritis

Identifiers

PMID42718558
PMCPMC13553240

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.