ArticleFrontiers in medicine2026
Identifying dendritic cell heterogeneity and potential risk genes in atopic dermatitis: integrative scRNA-seq, bulk RNA-seq analyses and experimental validation.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin condition marked by immune dysregulation and compromised skin barrier function, with dendritic cells (DCs) playing pivotal roles in its pathogenesis. This study aimed to systematically characterize the heterogeneity of DCs in AD, identify key pathogenic subsets and genes, and elucidate their regulatory mechanisms through advanced methodologies. We conducted integrated single-cell RNA sequencing (scRNA-seq) analyses on both AD lesions and normal skin samples, leading to the identification and functional annotation of distinct DC subtypes. Through deconvolution, pseudotime trajectory, and co-expression network analyses, we screened critical cell populations and candidate genes. Causal associations were assessed using Mendelian randomization and colocalization analyses, while transcription factor activity inference, kNN-DREMI, and motif analysis were employed to explore underlying regulatory mechanisms. Our results revealed five distinct DC subsets, with a notable expansion of CD207
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