ArticleFrontiers in dental medicine2026
Phytic acid and grape seed extract in dentin biomodification: effects on bond strength and interface integrity.
Article in Frontiers in dental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hybrid layer degradation, driven by residual matrix metalloproteinase (MMP) activity and hydrolytic attack at the resin-dentin interface, remains a primary cause of adhesive restoration failure. Dentin biomodification using natural cross-linking agents represents a promising strategy to enhance collagen stability and inhibit enzymatic degradation of the bonded interface. Objective: To evaluate and compare the effect of collagen cross linking agents, phytic acid (IP6) and grape seed extract (GSE), to reinforce the shear bond strength (SBS) of resin composite to dentin. Materials and methods: Enamel of 34 human maxillary premolars was eliminated and each tooth was sectioned to make a total sample size of 68 which was divided into four groups ( Results: G4-IP6 + GSE showed the highest SBS (23.44 ± 4.28 MPa), followed by G2-IP6 (21.51 ± 6.00 MPa) and G3-PA + GSE (21.01 ± 4.35 MPa), while G1-PA had the lowest values of 15.40 ± 4.60 MPa. FTIR analysis showed that phytic acid exhibited a broad peak at 3311.77 cm⁻ Conclusion: Phytic acid and grape seed extract significantly improved the composite-dentin shear bond strength of dentin. Their application appears to enhance the structural integrity of demineralized collagen at the resin-dentin interface, thereby supporting their potential incorporation into adhesive restorative protocols as a promising strategy to enhance dentin bond strength.
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