In one paragraphArticle in Stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
W Hudson RobbVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN (W.H.R., A.M.S., P.Z., D.S.K., T.B.J., N.S., K.R.P., Y.V., D.L., L.T.D., T.J.H., A.L.J.).ORCID 0000-0002-8952-7719 Ava M SantnerVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN (W.H.R., A.M.S., P.Z., D.S.K., T.B.J., N.S., K.R.P., Y.V., D.L., L.T.D., T.J.H., A.L.J.).ORCID 0009-0001-4160-1430 Panpan ZhangVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN (W.H.R., A.M.S., P.Z., D.S.K., T.B.J., N.S., K.R.P., Y.V., D.L., L.T.D., T.J.H., A.L.J.).ORCID 0000-0002-8211-5930 Darcie S KimVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN (W.H.R., A.M.S., P.Z., D.S.K., T.B.J., N.S., K.R.P., Y.V., D.L., L.T.D., T.J.H., A.L.J.).
T Bryan JacksonVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN (W.H.R., A.M.S., P.Z., D.S.K., T.B.J., N.S., K.R.P., Y.V., D.L., L.T.D., T.J.H., A.L.J.).ORCID 0000-0002-6318-1916 Niranjana ShashikumarVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN (W.H.R., A.M.S., P.Z., D.S.K., T.B.J., N.S., K.R.P., Y.V., D.L., L.T.D., T.J.H., A.L.J.).ORCID 0009-0006-5627-8281 Kimberly R PechmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN (W.H.R., A.M.S., P.Z., D.S.K., T.B.J., N.S., K.R.P., Y.V., D.L., L.T.D., T.J.H., A.L.J.).ORCID 0000-0003-0596-8064 Yukti VyasVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN (W.H.R., A.M.S., P.Z., D.S.K., T.B.J., N.S., K.R.P., Y.V., D.L., L.T.D., T.J.H., A.L.J.).ORCID 0000-0002-4815-3036 Dandan LiuVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN (W.H.R., A.M.S., P.Z., D.S.K., T.B.J., N.S., K.R.P., Y.V., D.L., L.T.D., T.J.H., A.L.J.).ORCID 0000-0002-7176-8346 L Taylor DavisVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN (W.H.R., A.M.S., P.Z., D.S.K., T.B.J., N.S., K.R.P., Y.V., D.L., L.T.D., T.J.H., A.L.J.).ORCID 0000-0003-2939-3875 Timothy J HohmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN (W.H.R., A.M.S., P.Z., D.S.K., T.B.J., N.S., K.R.P., Y.V., D.L., L.T.D., T.J.H., A.L.J.).ORCID 0000-0002-3377-7014 Angela L JeffersonVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN (W.H.R., A.M.S., P.Z., D.S.K., T.B.J., N.S., K.R.P., Y.V., D.L., L.T.D., T.J.H., A.L.J.).ORCID 0000-0002-8245-0587 Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MVanderbilt Memory & Aging ProjectR01AG034962 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2011 to 2025
$24.1MVanderbilt Alzheimer's Disease Research Center: REC CoreP30AG086403 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ANGELA L. JEFFERSON · 2025 to 2026
$15.0MVanderbilt Alzheimer's Disease Research CenterP20AG068082 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NEWHOUSE, PAUL A. · 2020 to 2023
$5.6MWhite matter and small vessel disease in older adultsR01AG056534 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2017 to 2021
$3.2MReplacement and Upgrade of a 3T MR Scanner for ResearchS10OD021771 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GORE, JOHN C · 2016 to 2016
$2.0MRisk factors and prevention targets for abnormal cognitive agingK24AG046373 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2014 to 2023
$1.7MHigh-Performance Computer Cluster for Biomedical ResearchS10OD023680 · OD · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2017 to 2017
$587kCerebrovascular neuroimaging markers and abnormal brain agingF31AG079640 · NIA · VANDERBILT UNIVERSITY · PI ROBB, WILLIAM HUDSON · 2022 to 2023
$63kNCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NIA NIH HHS F31 AG079640NIA NIH HHS K24 AG046373NIA NIH HHS P20 AG068082NIA NIH HHS P30 AG086403NIA NIH HHS R01 AG034962NIA NIH HHS R01 AG056534NIH HHS S10 OD021771NIH HHS S10 OD023680
6 · The paper itselfAbstract
backgroundHemodynamic insufficiency may contribute to the development of neuroimaging signs of cerebral small vessel disease (SVD). The arterial spin labeling (ASL) spatial coefficient of variation (ASL-sCoV) is a proxy marker of arterial transit time and may better capture SVD-related hemodynamic disturbances compared with ASL-derived cerebral blood flow. We investigated ASL-derived hemodynamic indices in relation to cognition and neuroimaging markers of SVD over an 11-year follow-up period.
methodsParticipants without dementia or stroke were enrolled in the Vanderbilt Memory and Aging Project, a longitudinal observational cohort study in Nashville, TN. Participants underwent serial multimodal 3T brain magnetic resonance imaging to quantify SVD burden and neuropsychological assessment from 2012 to 2024 (4.9±3.5 years mean follow-up). Pseudo-continuous ASL assessed cerebral blood flow and ASL-sCoV in total gray matter. Baseline ASL-sCoV and cerebral blood flow were individually related to the cross-sectional burden and longitudinal trajectory of each SVD neuroimaging marker (white matter hyperintensities, enlarged perivascular spaces, cerebral microbleeds, and lacunar infarcts) and cognitive performances using linear and linear mixed-effects regression models. Models were adjusted for demographics, cognitive status, Framingham Stroke Risk Profile (minus age),
resultsAmong participants (n=667, 68±9 years, 18% mild cognitive impairment, 51% female), higher ASL-sCoV was cross-sectionally associated with SVD markers, including white matter hyperintensities and enlarged perivascular spaces (
conclusionsASL-sCoV may serve as an important hemodynamic measure for identifying perfusion deficits tied to SVD burden and progression. Readily derived from existing ASL data sets, ASL-sCoV could provide substantial insight into the longitudinal clinical consequences of SVD.
Indexed as
arterial spin labelingcerebral blood flowcognitionneuroimagingwhite matter
Identifiers
PMID42717860
PMCPMC13564205
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