ArticleNMR in biomedicine2026
Technical Feasibility of IVIM for Prostate Cancer Imaging Using High-Amplitude Whole-Body Gradient System With Spiral Readout and Velocity-Compensated Diffusion Encoding.
Article in NMR in biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Intravoxel incoherent motion (IVIM) is sensitive to tissue diffusion and perfusion and has spurred great interest in various pathologies such as prostate cancer. However, poor repeatability and reproducibility of IVIM parameters hamper its wide-scale adoption in the clinics. To address this, improvements to the IVIM data acquisition and analysis are necessary. The purpose of this study was to develop a framework for high-quality IVIM imaging of the prostate. To boost signal precision and quality of IVIM parameter maps, we used a custom pulse sequence to combine velocity-compensated diffusion encoding with spiral readout at a high-performance 3 T MRI system with 300 mT/m gradients. IVIM parameters were evaluated in a cohort of five men with and without prostate cancer. Technical performance was assessed in terms of the signal-to-noise ratio (SNR), visual quality of IVIM parameter maps and parameter repeatability. High in-plane resolution images of the prostate were obtained with SNR > 3 (i.e., noise floor level) in 91% of voxels at the highest b-value of 500 s/mm
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