Evidence map›Paper›PMID 42717495›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton.

Lucie E Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N Jayash, Natalie Crump, Lucinda A E Evans, Maya Karmali, Worachet Promruk, Claire E Clarkin and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Lucie E BourneCentre For Lifelong Health, School of Applied Sciences, University of Brighton, Brighton, UK.ORCID https://orcid.org/0000-0003-3352-4946
Aikta SharmaDepartment of Mechanical Engineering, University College London, London, UK.ORCID https://orcid.org/0000-0002-5449-358X
Scott DillonYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0001-5609-8009
Jacob KeenSchool of Biological Sciences, University of Southampton, Southampton, UK.
Soher N JayashThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.ORCID https://orcid.org/0000-0001-5263-8557
Natalie CrumpCentre For Lifelong Health, School of Applied Sciences, University of Brighton, Brighton, UK.
Lucinda A E EvansCentre For Lifelong Health, School of Applied Sciences, University of Brighton, Brighton, UK.ORCID https://orcid.org/0000-0003-3411-1684
Maya KarmaliCentre For Lifelong Health, School of Applied Sciences, University of Brighton, Brighton, UK.ORCID https://orcid.org/0009-0002-4025-3160
Worachet PromrukThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.ORCID https://orcid.org/0009-0005-8268-1229
Claire E ClarkinSchool of Biological Sciences, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0001-6859-5897
Sonoko NarisawaHuman Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.ORCID https://orcid.org/0000-0002-2118-6380
Louise StephenThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.ORCID https://orcid.org/0000-0001-6795-0383
Brian L FosterDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0003-3444-0576
José Luis MillánHuman Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.ORCID https://orcid.org/0000-0002-1547-2671
Colin FarquharsonThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.ORCID https://orcid.org/0000-0002-4970-4039
Katherine A StainesCentre For Lifelong Health, School of Applied Sciences, University of Brighton, Brighton, UK.ORCID https://orcid.org/0000-0002-8492-9778

Funding

Identifying Novel Mechanisms for Dentoalveolar Mineralization Defects in X-linked HypophosphatemiaR01DE032334 · NIDCR · OHIO STATE UNIVERSITY · PI Brian Lee Foster · 2022 to 2026
$2.5M
Biotechnology and Biological Sciences Research Council BBS/E/D/10002071Biotechnology and Biological Sciences Research Council BBS/E/RL/230001CDiscovery Fellowship BB/X009904/1NIDCR NIH HHS R01 DE032334NIDCR NIH HHS R01DE032334UKRI Medical Research Council MR/R022240/2UKRI Medical Research Council MR/V033506/1
6 · The paper itself

Abstract

Biomineralization is essential for skeletal integrity, yet the synergistic roles of tissue non-specific alkaline phosphatase (TNAP) and PHOSPHO1 in postnatal bone remain unclear. We generated a novel murine model with Prx1-driven deletion of Alpl (Alpl

Indexed as

biomineralizationbone, murine modelPhospho1Tissue non‐specific alkaline phosphatase

Identifiers

PMID42717495
PMCPMC13558897

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.