ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Mutant KRAS-m
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang and 3 more
Abstract read
In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Danyu Chen *Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key, Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-2202-2863 Pingmei Huang *Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key, Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-4893-8159 Ruizhi Tao *Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key, Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Fenfen JiInstitute of Digestive Disease and Department of Medicine and Therapeutics, State Key, Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-2265-7607 Qinyao WeiInstitute of Digestive Disease and Department of Medicine and Therapeutics, State Key, Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Lok Hin KoInstitute of Digestive Disease and Department of Medicine and Therapeutics, State Key, Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0009-0006-3281-2566 Lianxin ZhouInstitute of Digestive Disease and Department of Medicine and Therapeutics, State Key, Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Alvin CheungDepartment of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Wei KangDepartment of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-4651-677X Ko Fai ToDepartment of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0003-4919-3707 Jun YuInstitute of Digestive Disease and Department of Medicine and Therapeutics, State Key, Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0001-5008-2153 Chi Chun WongInstitute of Digestive Disease and Department of Medicine and Therapeutics, State Key, Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0003-1362-3541 Funding
Health and Medical Research Fund 08190706Health and Medical Research Fund 22210122National Nature Science Foundation of China 2023ZD0500200National Nature Science Foundation of China 2023ZD0501400National Nature Science Foundation of China 82504203Research Grants Council (RGC)-General Research Fund 14101322Research Grants Council (RGC)-General Research Fund 14101725RGC-Collaborative Research Fund C4008-23WFRGC-Collaborative Research Fund C4042-24GF
6 · The paper itselfAbstract
The interaction between gene mutations and epitranscriptomic alterations in colorectal cancer (CRC) remains poorly understood. Here, we identified that KRAS mutations, present in ∼40%-50% of CRC patients, act as driver mutations mediating an aberrant epitranscriptome. In human CRC patients, mutant KRAS correlates with increased m
Indexed as
autophagybiologycancer researchcd34gene mutationkrasmutanttumor microenvironment
Identifiers
PMID42717493
PMCPMC13558909
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