Evidence map›Paper›PMID 42717423›Full record

ArticleActa physiologica (Oxford, England)2026

Impaired Hepatic Glucose Metabolism Is Associated With Glucose Intolerance in Mice Carrying α

Christian Staehr, Tue Duy Nguyen, Tina Myhre Pedersen, Mikkel Vendelbo, Hans Christian Beck, Mads Kjolby, Rajkumar Rajanathan, Elena V Bouzinova, Niels Jessen, Per Bendix Jeppesen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Christian StaehrDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-5431-4409
Tue Duy NguyenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Tina Myhre PedersenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-7950-4647
Mikkel VendelboDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Hans Christian BeckDepartment of Clinical Biochemistry, Odense University Hospital, Odense, Denmark.ORCID https://orcid.org/0000-0002-7763-3637
Mads KjolbyDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-1043-6137
Rajkumar RajanathanDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Elena V BouzinovaDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-9511-8009
Niels JessenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-5613-7274
Per Bendix JeppesenDepartment of Clinical Medicine, Aarhus University, Aarhus N, Denmark.ORCID https://orcid.org/0000-0001-8042-7554
Alexander V ChibalinDepartment of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-6339-6271
Vladimir V MatchkovDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-3303-1095

Funding

Danmarks Frie Forskningsfond 3101-00103BLundbeck Foundation R344-2020-952Lundbeck Foundation R412-2022-449Novo Nordisk Fonden NNF18OC0052021Novo Nordisk Fonden NNF19OC0056371
6 · The paper itself

Abstract

aimThe Na,K-ATPase is important for energy demanding cellular processes, including essential components of substrate metabolism and metabolic flexibility. Mice heterozygous for the hemiplegic migraine-related mutation, G301R, of the Na,K-ATPase α

methods3- and 8-month-old α

resultsThe 3-month-old α

conclusionsMigraine-associated mutation of the Na,K-ATPase α

Indexed as

GlucoseGlucose IntoleranceLiverSodium-Potassium-Exchanging ATPaseAnimalsFemaleMaleMiceMutationAtp1a2 protein, mouseGlucoseSodium-Potassium-Exchanging ATPase

Identifiers

PMID42717423
PMCPMC13558787

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.