ArticleClinical and translational science2026
Interventional Feasibility Study Investigating Virtual Reality-Based Gait Assessment With Orthoses in People With Multiple Sclerosis: A Study Protocol.
Article in Clinical and translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07096700 (Virtual Reality for Gait Training in Multiple Sclerosis), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Virtual Reality for Gait Training in Multiple Sclerosis (VIRTUE): an Interventional Feasibility Study
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0 citing papers in PubMed.
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) often leads to significant impairments in gait and mobility. Although walking braces are commonly prescribed, their real-world effectiveness is limited by insufficient adaptation. Traditional clinical assessments rely on subjective scales and may not fully reflect daily-life challenges. Immersive virtual reality (VR) and wearable sensors offer promising solutions for ecological monitoring, but their combined use remains unvalidated for orthotic support in MS. This interventional study examines the feasibility of a novel, VR-based framework designed to support gait assessment with a passive walking brace. Twelve participants with MS will undergo a protocol combining four ambulatory sessions and a week-long home-monitoring phase. Standardized gait tests will be performed with and without the brace across both simulated scenarios and real-world conditions. Multimodal data collected via inertial and physiological wearable sensors will characterize spatiotemporal gait parameters, balance, posture, and physiological responses, alongside standardized clinical scales and subjective questionnaires. Overall feasibility will be evaluated directly through user usability and acceptability, recruitment and retention rates, safety, protocol adherence, and data completeness. Given that this pilot study is not powered to assess clinical efficacy, statistical analysis will focus strictly on descriptive and exploratory comparisons across conditions and sessions. This translational framework aims to establish robust feasibility metrics to support the design of future, larger-scale controlled trials. Ultimately, these preliminary observations will inform more ecologically valid, personalized rehabilitation strategies to improve the integration of assistive technologies into patients' daily lives. Trial Registration: ClinicalTrials.gov, NCT07096700. Registered July 24, 2025.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.