ArticleInternational journal of urology : official journal of the Japanese Urological Association2026
Cancer-Control Outcomes of Japanese Vs. German Metastatic Hormone-Sensitive Prostate Cancer Patients: A Real-World Cross-Country Comparison of Patients Undergoing Combination Therapies.
Article in International journal of urology : official journal of the Japanese Urological Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDifferences in tumor biology, ethnicities, and healthcare structures across populations may contribute to variability in oncologic outcomes. This study compared baseline characteristics and oncologic outcomes of Japanese and German metastatic hormone-sensitive prostate cancer (mHSPC) patients.
methodsA pooled analysis of 1 215 mHSPC patients from Japan (JIKEI-YAYOI database, n = 639) and Germany (FRAMCAP database, n = 576) undergoing combination therapies between 2015 and 2025 was performed. Cox regression models were used to evaluate time to castration-resistant prostate cancer (ttCRPC) and overall survival (OS). Propensity score matched analyses (PSM) validation was performed.
resultsJapanese patients were older at diagnosis (median 73 vs. 70 years) and had higher PSA at mHSPC diagnosis (260 vs. 43 ng/mL). Moreover, Japanese patients had more frequently synchronous mHSPC (95% vs. 75%), high-volume disease (78% vs. 54%), and visceral metastases (16% vs. 8%). ADT plus androgen receptor pathway inhibitors (ARPI) was used more frequently in Japan (76% vs. 71%), as was the combination of ADT + ARPI + docetaxel (17% vs. 11%). Conversely, ADT + docetaxel was less commonly used in Japan (7% vs. 19%). Median ttCRPC was 39 vs. 23 months, and median OS was 80 vs. 51 months (Japan vs. Germany). After adjustment for relevant clinical covariates, Japanese cohort affiliation remained an independent predictor of prolonged ttCRPC (HR 0.53, p < 0.001) and improved OS (HR 0.54, p < 0.001). PSM analyses confirmed similar findings.
conclusionsDespite presenting with more adverse baseline characteristics, Japanese mHSPC patients demonstrated longer ttCRPC and improved OS compared with patients in Germany. These differences may reflect not only potential biological variations but also differences in treatment strategies and healthcare structures.
trial registrationNot applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.