Evidence map›Paper›PMID 42717250›Full record

ArticleNature neuroscience2026

SORDINO: silent, sensitive, specific and artifact-resistant fMRI in awake, behaving mice.

Martin J MacKinnon, Sheng Song, Tzu-Hao Harry Chao, Li-Ming Hsu, Scott T Albert, Yuncong Ma, Tatiana A Shnitko, Tzu-Wen Winnie Wang, Randy J Nonneman, Corey D Freeman and 11 more

Abstract read
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In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Mapping cardiac and respiratory pulsations simultaneously with functional connectivity in the rat brain using zero echo time fMRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  5. Article
  6. Review
  7. Charting the path in rodent functional neuroimaging.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Martin J MacKinnon *Center for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sheng Song *Center for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tzu-Hao Harry Chao *Center for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-0057-6849
Li-Ming HsuCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-9296-344X
Scott T AlbertNeuroscience Center and Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yuncong MaCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tatiana A ShnitkoCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-7872-7408
Tzu-Wen Winnie WangCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-3413-7817
Randy J NonnemanCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Corey D FreemanNeuroscience Center and Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Samuel BoothCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Siddhi S OzarkarNeuroscience Center and Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Paul B ManisDepartment of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-0131-8961
Uzay E EmirCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Eric R MuirCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Mark D ShenNeuroscience Center and Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-1190-7981
Benjamin D PhilpotNeuroscience Center and Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-2746-9143
Adam W HantmanNeuroscience Center and Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-6563-1423
Sung-Ho LeeCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-5292-0747
Wei-Tang ChangBiomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yen-Yu Ian ShihCenter for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. shihy@unc.edu.ORCID http://orcid.org/0000-0001-6529-911X

Funding

UNC ARC Information/Dissemination CoreP60AA011605 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Clyde W Hodge · 2003 to 2026
$46.3M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
Postdoctoral Research in Neurodevelopmental DisordersT32HD040127 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BENJAMIN D PHILPOT, Mark D Shen · 2001 to 2026
$8.5M
UNC-CH NADIA Underage Drinking and Adult Brain Morphology in RatsU01AA020023 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CREWS, FULTON T · 2010 to 2024
$7.5M
Circuit Mechanisms Governing the Default Mode NetworkR01MH126518 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Vinod Menon, Yen-Yu Ian Shih · 2021 to 2026
$4.3M
Mechanisms underlying positive and negative BOLD in the striatumRF1MH117053 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2018 to 2019
$4.0M
Chemogenetic Dissection of Neuronal and Astrocytic Compartment of the BOLD SignalR01MH111429 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2016 to 2020
$2.7M
SORDINO-fMRI for mouse brain applicationsR01EB033790 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Yen-Yu Ian Shih · 2023 to 2026
$2.5M
Functional dissection of therapeutic deep brain stimulation circuitryR01NS091236 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2015 to 2019
$2.0M
9.4T Small Animal MRI scanner at UNCS10OD026796 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2020 to 2020
$2.0M
AVANCE NEO upgrade for the BioSpec 9.4T/30cm MRI system at UNCS10MH124745 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2020 to 2020
$600k
Concurrent high resolution calcium imaging and fMRI reveal intra anterior cingulate cortex neuronal activity and large-scale brain network connectivity in healthy and nicotine-addicted miceR21DA057503 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HSU, LI-MING, SHIH, YEN-YU IAN · 2023 to 2024
$428k
NIAAA NIH HHS P60 AA011605NIAAA NIH HHS U01 AA020023NIBIB NIH HHS R01 EB033790NICHD NIH HHS P50 HD103573NICHD NIH HHS T32 HD040127NIDA NIH HHS R21 DA057503NIH HHS S10 OD026796NIMH NIH HHS R01 MH111429NIMH NIH HHS R01 MH126518NIMH NIH HHS RF1 MH117053NIMH NIH HHS S10 MH124745NINDS NIH HHS R01 NS091236NINDS NIH HHS R21 NS133913U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) P50HD103573; T32HD040127U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) R01EB033790U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) RF1MH117053; R01MH126518; R01MH111429; S10MH124745U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) P60AA011605; U01AA020023U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R21DA057503U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) S10OD026796W. M. Keck Foundation (W.M. Keck Foundation) N/A
6 · The paper itself

Abstract

Blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) has advanced brain mapping across species. This widely used technique, however, faces challenges such as acoustic noise, electromagnetic interference, motion artifacts, magnetic-field inhomogeneity and limitations in sensitivity and specificity. Here we introduce Steady-state On-the-Ramp Detection of INduction-decay with Oversampling (SORDINO), an improved zero echo time (ZTE)-based fMRI technique that maintains ultra-low slew rate and acquires data exclusively during gradient direction changes. At 9.4 T, SORDINO outperforms conventional gradient-recalled-echo-based echo-planar imaging and ZTE in metrics crucial for fMRI while being silent, sensitive, specific and resistant to motion and susceptibility artifacts. We showcase SORDINO's superior compatibility with multimodal experiments and reveal T

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.