Evidence map›Paper›PMID 42717237›Full record

ArticleExperimental & molecular medicine2026

SMRT regulation of nuclear receptors orchestrates bile acid homeostasis.

Kyeongkyu Kim, Sungsoon Fang, Suk-Hyun Hong, Han Cho, Mathias Leblanc, Sandra Jacinto, Bernd Schnabl, Annette R Atkins, Ruth T Yu, Christopher Liddle and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental & molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kyeongkyu Kim *Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Sungsoon Fang *Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-0201-5567
Suk-Hyun HongGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Han ChoGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Mathias LeblancGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Sandra JacintoGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Bernd SchnablDepartment of Medicine, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-6281-825X
Annette R AtkinsGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Ruth T YuGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Christopher LiddleStorr Liver Unit, Westmead Millennium Institute, University of Sydney, Sydney, Australia.
Morgan L TruittGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Weiwei FanGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Chae Min LeeDepartment of Biomedical Sciences and Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0009-0008-7290-4304
Michael DownesGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA. downes@salk.edu.ORCID http://orcid.org/0000-0002-6351-9585
Ronald M EvansGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA. evans@salk.edu.ORCID http://orcid.org/0000-0002-9986-5965

Funding

HORMONAL REGULATION OF MAMMALIAN GENE EXPRESSIONR37DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2000 to 2019
$16.0M
Tissue-specific roles of FXR in CVD and NASHP01HL147835 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT · 2020 to 2024
$12.2M
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8M
Hormonal Regulation of Mammalian Gene ExpressionR01DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2021 to 2024
$2.6M
Larry L. Hillblom Foundation (Larry L. Hillblom Foundation, Inc.) 2021-D-001-NETMarch of Dimes Foundation (March of Dimes) Endowed ChairNHLBI NIH HHS P01 HL147835NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK057978NIDDK NIH HHS R37 DK057978NOMIS Stiftung (NOMIS Foundation) Distinguished Scholar AwardUnited States Department of Defense | United States Navy | Office of Naval Research (ONR) N00014-16-1-3159U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) P01HL147835U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK057978U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK120515
6 · The paper itself

Abstract

Nuclear receptors are key effectors of metabolic programs; however, the contribution of co-regulatory complexes in maintaining metabolic homeostasis is not fully understood. Here, we show that modulation of the constitutive androstane receptor (CAR) by the co-repressor silencing mediator of retinoic acid and thyroid hormone receptors (SMRT) is required for bile acid (BA) homeostasis. Transcriptional changes in the livers of mice harboring a targeted disruption in one of the nuclear receptor-interacting domains (RIDs), SMRT

Indexed as

Bile Acids and SaltsHomeostasisNuclear Receptor Co-Repressor 2Receptors, Cytoplasmic and NuclearAnimalsConstitutive Androstane ReceptorGene Expression RegulationHumansLiverMaleMiceReceptor, Farnesoid X-ActivatedBile Acids and SaltsConstitutive Androstane ReceptorNcor2 protein, mouseNuclear Receptor Co-Repressor 2Receptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and Nuclear

Identifiers

PMID42717237
PMCPMC13633267

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.