Evidence map›Paper›PMID 42717236›Full record

ArticleExperimental & molecular medicine2026

HDAC1 maintains metabolic homeostasis in nucleus pulposus cells via post-translational modification interactions with YBX1.

Bohao Zhou, Jiechao Xia, Zhaowei Zhang, Bingbing Xu, Zixin Ruan, Tianyou Gao, Chen'an You, Fengjie Ma, Zhenlei Zhang, Teng Yao and 9 more

Abstract read
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In one paragraph

Article in Experimental & molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Bohao Zhou *Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID http://orcid.org/0009-0009-7754-398X
Jiechao Xia *Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhaowei Zhang *Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Bingbing XuSchool of Medicine, Shaoxing University, Shaoxing, Zhejiang, China.
Zixin RuanSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, China.
Tianyou GaoSchool of Medicine, Shaoxing University, Shaoxing, Zhejiang, China.
Chen'an YouDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Fengjie MaDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhenlei ZhangDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Teng YaoDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jun GaoDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jianle WangDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zheyuan ZhangDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Junxin ChenDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Shiyuan ShiDepartment of Orthopaedic Surgery, Hangzhou Ninth People's Hospital, Hangzhou, China.
Yongfeng CuiDepartment of Orthopaedic Surgery, Hangzhou Ninth People's Hospital, Hangzhou, China.
Panyang ShenDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. shenpanyang@zju.edu.cn.
Shuying ShenDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. 11207057@zju.edu.cn.ORCID http://orcid.org/0000-0002-4523-8501
Jianjun MaDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. sealteam@zju.edu.cn.ORCID http://orcid.org/0000-0001-9462-1534

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervertebral disc degeneration is characterized by the metabolic dysregulation of nucleus pulposus cells, which is regulated by complex post-translational modifications, manifesting as extracellular matrix remodeling and inflammatory microenvironment formation. We demonstrated the progressive downregulation of HDAC1 during disc degeneration. HDAC1 mediates the deacetylation and ubiquitination-dependent degradation of YBX1. The downregulation of HDAC1 results in YBX1 accumulation, compromising extracellular matrix synthesis in nucleus pulposus cells while enhancing the degradation processes. Furthermore, the accumulated YBX1 stimulates chemokine expression, facilitating the development of an inflammatory microenvironment. Targeting this critical axis, we developed SU056@GelMA to deliver the YBX1 inhibitor SU056, mitigating the metabolic disruption induced by YBX1 accumulation.

Indexed as

Histone Deacetylase 1HomeostasisNucleus PulposusProtein Processing, Post-TranslationalY-Box-Binding Protein 1AnimalsHumansIntervertebral Disc DegenerationUbiquitinationHDAC1 protein, humanHistone Deacetylase 1Y-Box-Binding Protein 1YBX1 protein, human

Identifiers

PMID42717236
PMCPMC13633268

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.