Reduced sensorimotor lactate concentration and improved sleep efficiency following resistance training in older adults.

Selin Scherrer, Sven Egger, Xinyu Liu, Anna Zoé Wick, Björn Rasch, Lijing Xin, Benedikt Lauber, Wolfgang Taube

Abstract read

In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Selin ScherrerDepartment of Neuro- and Movement Sciences, University of Fribourg, Boulevard de Pérolles 90, CH-1700, Fribourg, Switzerland. selin.scherrer@unifr.ch.ORCID http://orcid.org/0000-0003-4476-6633

Sven EggerDepartment of Neuro- and Movement Sciences, University of Fribourg, Boulevard de Pérolles 90, CH-1700, Fribourg, Switzerland.ORCID http://orcid.org/0000-0002-4623-7201

Xinyu LiuLaboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, CH-1015, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-0567-5264

Anna Zoé WickDepartment of Psychology, University of Fribourg, CH-1700, Fribourg, Switzerland.ORCID http://orcid.org/0009-0003-7364-7243

Björn RaschDepartment of Psychology, University of Fribourg, CH-1700, Fribourg, Switzerland.ORCID http://orcid.org/0000-0001-7607-3415

Lijing XinCIBM Center for Biomedical Imaging, CH-1015, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-5450-6109

Benedikt LauberDepartment of Neuro- and Movement Sciences, University of Fribourg, Boulevard de Pérolles 90, CH-1700, Fribourg, Switzerland.ORCID http://orcid.org/0000-0001-9684-3675

Wolfgang TaubeDepartment of Neuro- and Movement Sciences, University of Fribourg, Boulevard de Pérolles 90, CH-1700, Fribourg, Switzerland.ORCID http://orcid.org/0000-0002-8802-2065

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 32003B_197687

6 · The paper itself

Abstract

As populations age worldwide, pathological neurodegeneration with subsequent cognitive decline has emerged as a pressing public health challenge. As effective treatments remain limited once neurodegeneration has occurred, prevention and delay of decline onset are crucial. While physical exercise is associated with improved cognition, exercise-specific mechanisms remain unclear. We therefore examined the effects of 12 weeks explosive lower-body resistance training (RT) in community-dwelling older adults on proposed markers associated with brain metabolism and sleep. Thirty-six participants (64-81 years) completed pre and post assessments consisting of sensorimotor lactate and N-acetylaspartate (NAA) levels via 7 T magnetic resonance spectroscopy (analyzable lactate data: n = 24; NAA: n = 32), objective sleep architecture with wearable polysomnography (n = 34), and subjective sleep quality of the recorded nights with the revised sleep questionnaire A (n = 25) as well as of the preceding 4 weeks with the Pittsburgh Sleep Quality Index (n = 36). Participants were assigned to RT (3 sessions per week) or a control group (CON; maintaining lifestyle). After significant Group × Time interactions via repeated-measures ANCOVA with sex as covariate, paired t-tests revealed that RT significantly (p < 0.05) reduced resting lactate concentration (d = 0.78), improved objective sleep efficiency (d = 0.75), and prolonged total sleep time (d = 0.61). Our findings suggest that resistance training may be particularly beneficial for older adults experiencing fragmented sleep and impaired neural oxidative metabolism.

Indexed as

Brain metabolismExercise interventionHealthy agingResistance trainingSleep quality

Identifiers

PMID42717164

DOI10.3390/biomedicines13051121

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.