Evidence map›Paper›PMID 42717156›Full record

ArticleEmergency radiology2026

Diagnostic yield of repeat CT pulmonary angiography after a negative examination in the emergency department.

Natalia Gorelik, Tiffany Fung, Eliana Sacher, Lorenna Mendonça de Albuquerque, Joseph Najjar, Erfan Sadri, Sylvain Grange, José A Correa

Abstract read
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In one paragraph

Article in Emergency radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Natalia GorelikDepartment of Diagnostic Radiology, Faculty of Medicine and Health Sciences, McGill University, 3605 de la Montagne Street, Montréal, QC, H3G 2M1, 514-934-1934, Canada. natalia.gorelik@mail.mcgill.ca.ORCID http://orcid.org/0000-0001-9672-6807
Tiffany FungDepartment of Diagnostic Radiology, Faculty of Medicine and Health Sciences, McGill University, 3605 de la Montagne Street, Montréal, QC, H3G 2M1, 514-934-1934, Canada.
Eliana SacherDepartment of Diagnostic Radiology, Faculty of Medicine and Health Sciences, McGill University, 3605 de la Montagne Street, Montréal, QC, H3G 2M1, 514-934-1934, Canada.
Lorenna Mendonça de AlbuquerqueCancer Research Program, Research Institute of the McGill University Health Centre, 1001 Décarie Blvd, Montréal, QC, H4A 3J1, Canada.ORCID http://orcid.org/0009-0005-4111-9475
Joseph NajjarDepartment of Diagnostic Radiology, Faculty of Medicine and Health Sciences, McGill University, 3605 de la Montagne Street, Montréal, QC, H3G 2M1, 514-934-1934, Canada.ORCID http://orcid.org/0009-0005-3889-8674
Erfan SadriDepartment of Diagnostic Radiology, Faculty of Medicine and Health Sciences, McGill University, 3605 de la Montagne Street, Montréal, QC, H3G 2M1, 514-934-1934, Canada.ORCID http://orcid.org/0009-0001-9203-3920
Sylvain GrangeDepartment of Diagnostic Radiology, Faculty of Medicine and Health Sciences, McGill University, 3605 de la Montagne Street, Montréal, QC, H3G 2M1, 514-934-1934, Canada.ORCID http://orcid.org/0000-0003-3706-297X
José A CorreaDepartment of Mathematics and Statistics, McGill University, Burnside Hall, Room 1010, 805 Sherbrooke Street West, Montreal, QC, H3A 0B9, Canada.

Funding

Fonds de Recherche du Québec - Santé Fonds de Recherche du Québec - Santé
6 · The paper itself

Abstract

purposeAlthough repeat CT pulmonary angiography (CTPA) after a negative index examination in the emergency department (ED) is common, its diagnostic utility remains uncertain. This study aimed to determine the incidence and diagnostic yield of repeat CTPA after a negative index examination in the ED.

methodsThis retrospective cohort study included adults undergoing CTPA across three EDs at our center from 2016 to 2017. CTPA results were classified as positive, negative, or other (equivocal or negative with reported limitations) based on radiology reports. Patients with a negative index CTPA were followed for two years to identify repeat examinations. Diagnostic yield of repeat CTPA at 1 month, 1 year, and 2 years was compared with that of the index examination using a likelihood ratio test for nested proportions.

resultsAmong 3,112 patients (median age, 60.1 years; 59.1% women), 331 (10.6%) had a positive index CTPA. Of 2,412 patients with a negative index examination, 297 (12.3%) underwent repeat CTPA within 2 years, including 202 (8.4%) performed in our ED. The diagnostic yield of repeat CTPA performed in our ED was lower than that of the index examination: 3.8% (1/26; p = 0.20) at 1 month, 6.0% (9/150; p = 0.051) at 1 year, and 6.4% (13/202; p = 0.04) at 2 years.

conclusionRepeat CTPA after a negative examination demonstrated a lower diagnostic yield than initial imaging, highlighting an opportunity for more selective use of repeat CTPA guided by clinical pretest probability.

Indexed as

Clinical Decision RulesComputed Tomography Pulmonary AngiographyDiagnostic YieldImaging OverusePulmonary EmbolismRepeat Imaging

Identifiers

PMID42717156

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.