SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Clinical, Laboratory and Radiological Factors associated with posterior reversible encephalopathy syndrome (PRES) in patients with eclampsia or pre-eclampsia: a systematic review and meta-analysis.
Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPosterior reversible encephalopathy syndrome (PRES) remains a serious neurological complication associated with eclampsia/pre-eclampsia. Early identification remains challenging due to heterogeneous presentations and limited consensus on associated clinical and laboratory factors. Therefore, we aimed to assess clinical and laboratory factors associated with PRES by pooling data from primary studies.
methodsA systematic review was conducted following PRISMA 2020 guidelines. PubMed, Embase, and Web of science were searched from inception to March 25, 2025. Primary outcomes included PRES incidence, while secondary outcomes included biomarkers, maternal and fetal outcomes, and imaging characteristics. Risk of bias was assessed using Newcastle Ottawa's scale and National Institutes of Health (NIH) tool. A random-effects model was employed for meta-analysis.
resultsA total of 28 studies were included. The pooled incidence of PRES was 38.68% (95% CI: 29.63-48.59), with significant heterogeneity (I²=98.5%). Patients with PRES had significantly higher liver enzymes (ALT: MD 35.88 IU/L; AST: MD 48.69 IU/L) and lower platelet counts (MD: -31.15 × 10⁹/L). Total bilirubin was also elevated. Maternal mortality risk was increased but not statistically significant (RR: 4.06), while stillbirth and preterm birth showed no significant associations. Imaging findings commonly involved the frontal (43.05%) and temporal lobes (20.33%).
conclusionPRES is a frequent complication of pre-eclampsia and eclampsia, with identifiable clinical and biochemical factors associated with its occurrence, particularly elevated liver enzymes and thrombocytopenia. Despite substantial heterogeneity, these findings may help inform clinical assessment, especially in resource-limited settings. Further high-quality prospective studies are needed to develop standardized predictive models and improve early detection.
Indexed as
Identifiers
42717136What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.