ArticleWiener klinische Wochenschrift2026
Outcomes of a multidisciplinary lifestyle intervention in adults with Down syndrome : A retrospective observational study.
Article in Wiener klinische Wochenschrift, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAdults with Down syndrome are at increased risk of obesity and cardiometabolic disease; however, evidence regarding effective lifestyle interventions remains limited. This study evaluated the outcomes of a multidisciplinary lifestyle program incorporating nutritional therapy in adults with Down syndrome attending a specialized outpatient clinic.
methodsThis retrospective observational study included adults with genetically confirmed Down syndrome aged ≥ 18 years with overweight or obesity (body mass index, BMI> 25 kg/m
resultsIn this study nine participants met the inclusion criteria and five completed the intervention and follow-up assessments. Mean baseline BMI was 36.0 ± 6.0 kg/m
conclusionThis retrospective study demonstrates the feasibility of implementing a multidisciplinary lifestyle intervention incorporating nutritional therapy for adults with Down syndrome and obesity in a specialized outpatient setting. The findings provide preliminary clinical experience regarding the provision of a tailored interventional approach in this population. Larger prospective studies are required to further evaluate multidisciplinary lifestyle programs and their long-term relevance for metabolic health and quality of life.
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