Evidence map›Paper›PMID 42717098›Full record

ArticleNature2026

An operational perturbation proteomics-based virtual cell model.

Rui Sun, Liujia Qian, Yongge Li, Tong Liu, Honghan Cheng, Xuedong Zhang, Xueya Zhou, Yuecheng Zhan, Guangmei Zhang, Zhengchao Luo and 23 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Rui Sun *Affiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.ORCID http://orcid.org/0000-0002-8484-8089
Liujia Qian *Affiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.
Yongge Li *DP Technology Co., Ltd, Beijing, China.ORCID http://orcid.org/0000-0003-3261-4448
Tong Liu *Department of Surgical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.ORCID http://orcid.org/0000-0001-9234-1328
Honghan ChengAffiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.ORCID http://orcid.org/0009-0006-4901-3314
Xuedong ZhangAffiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.
Xueya ZhouDP Technology Co., Ltd, Beijing, China.
Yuecheng ZhanWestlake Omics Co., Ltd, Hangzhou, China.
Guangmei ZhangAffiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.
Zhengchao LuoDP Technology Co., Ltd, Beijing, China.ORCID http://orcid.org/0009-0005-4917-2967
Kunpeng MaAffiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.
Chunlong WuAffiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.
Dongchen JiDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
Zhangzhi XueAffiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.ORCID http://orcid.org/0000-0001-7311-6221
Hongxue MengDepartment of Pathology, Harbin Medical University Cancer Hospital, Harbin, China.
Yuhang XiangDepartment of Pathology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Dingwei LeiDP Technology Co., Ltd, Beijing, China.ORCID http://orcid.org/0009-0006-0194-0952
Qianhe ZhouDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
Wenbin HuWestlake Omics Co., Ltd, Hangzhou, China.
Yuhan DengDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
Lingling TanWestlake Omics Co., Ltd, Hangzhou, China.
Qi XiaoAffiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.
Zhiwei LiuAffiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.ORCID http://orcid.org/0009-0002-9353-015X
Lei ZengAffiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.
Liqin QianAffiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.
Xuan ZhengAffiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.
Qiong HuAffiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.
Nianzi LuoAffiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.
Weinan ECenter for Machine Learning Research, Peking University, Beijing, China.
Peijie ZhouCenter for Machine Learning Research, Peking University, Beijing, China. pjzhou@pku.edu.cn.ORCID http://orcid.org/0000-0002-4585-2923
Han WenDP Technology Co., Ltd, Beijing, China. wenh@aisi.ac.cn.ORCID http://orcid.org/0000-0003-4680-4218
Yi ZhuAffiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China. zhuyi@westlake.edu.cn.ORCID http://orcid.org/0000-0003-0429-0802
Tiannan GuoAffiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China. guotiannan@westlake.edu.cn.ORCID http://orcid.org/0000-0003-3869-7651

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial intelligence-empowered virtual cell models represent an emerging approach for in silico drug discovery

Identifiers

PMID42717098

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.