Evidence map›Paper›PMID 42717089›Full record

ArticleNature2026

Within-family effect of ancestry on complex traits in a Mexican population.

Siqi Wang, Jaime Berumen, Alejandra Vergara-Lope, Paulina Baca, Elizabeth Barrera, Fernando Rivas, Diego Aguilar-Ramirez, Rory Collins, Jonathan R Emberson, Michael Hill and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Siqi Wang *Nuffield Department of Population Health, University of Oxford, Oxford, UK. siqi.wang@ndph.ox.ac.uk.ORCID http://orcid.org/0000-0002-4154-2266
Jaime Berumen *Experimental Research Unit from the Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID http://orcid.org/0000-0001-6707-3317
Alejandra Vergara-LopeNuffield Department of Population Health, University of Oxford, Oxford, UK.
Paulina BacaExperimental Research Unit from the Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
Elizabeth BarreraExperimental Research Unit from the Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID http://orcid.org/0009-0005-6168-8173
Fernando RivasExperimental Research Unit from the Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID http://orcid.org/0009-0004-7744-0044
Diego Aguilar-RamirezNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-2298-3768
Rory CollinsNuffield Department of Population Health, University of Oxford, Oxford, UK.
Jonathan R EmbersonNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-7792-9422
Michael HillNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-3861-6105
Michael E GoddardCentre for AgriBioscience, Agriculture Victoria, Melbourne, Victoria, Australia.
Loic YengoInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Alexander Strudwick YoungHuman Genetics Department, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Jesus Alegre-DíazExperimental Research Unit from the Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID http://orcid.org/0000-0001-9390-3871
Pablo Kuri-MoralesTecnológico de Monterrey, Proyecto OriGen, Monterrey, Mexico.ORCID http://orcid.org/0000-0002-0704-9507
Roberto Tapia-ConyerFaculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID http://orcid.org/0000-0003-3814-2904
Jason M TorresNuffield Department of Population Health, University of Oxford, Oxford, UK. jason.torres@ndph.ox.ac.uk.ORCID http://orcid.org/0000-0002-7537-7035
Peter M VisscherNuffield Department of Population Health, University of Oxford, Oxford, UK. peter.visscher@ndph.ox.ac.uk.ORCID http://orcid.org/0000-0002-2143-8760

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human populations differ in disease prevalence and phenotypes, but the extent to which differences are caused by genetic factors is unknown for most complex traits. Comparing phenotypic means across populations is confounded by environmental differences and using polygenic predictors can lead to biased inference

Identifiers

PMID42717089

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.