Evidence map›Paper›PMID 42717083›Full record

ArticleNature2026

TM184C is a GPCR-like regulator of intercellular exchange and autophagy.

Kyutae D Lee, Samuel Taylor, Jennifer Arcuri, Shraddha Chandthakuri, Jacinda Pujols, Bruno Colon, Qiang Wang, Chenzhou Wu, Zhipeng Meng, Sebastian J Thompson-Ceccato and 12 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Kyutae D Lee *Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0000-0002-0348-8019
Samuel Taylor *Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0009-0009-7026-2181
Jennifer Arcuri *Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.
Shraddha ChandthakuriDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0000-0002-6278-5048
Jacinda PujolsDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0000-0002-3728-9130
Bruno ColonDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.
Qiang WangDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.
Chenzhou WuDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.
Zhipeng MengDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0000-0003-4756-6303
Sebastian J Thompson-CeccatoDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0009-0002-2919-4155
Jonathan MitchellDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.
Defne BayikDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0000-0002-4740-8869
Alexandra CarboneSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Vladlen SlepakDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.
Tatiana I SlepakDepartment of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Scott M WelfordSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Michael E IvanSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0000-0002-4798-4989
Dazhi WangDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.
Blake O GoldbergDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0009-0008-1369-356X
Warner BaringerDepartment of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Elvis MaradzikeDepartment of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Daniel G IsomDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA. disom@miami.edu.ORCID http://orcid.org/0000-0001-5637-2370

Funding

pH regulation of cell surface receptorsR35GM119518 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Daniel Isom · 2016 to 2026
$4.1M
Polyamine Catabolism and Therapeutic Resistance in Glioblastoma MultiformeR01CA187053 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI WELFORD, SCOTT MICHAEL · 2015 to 2025
$3.5M
NCI NIH HHS R01 CA187053NIGMS NIH HHS R35 GM119518
6 · The paper itself

Abstract

Sequence similarity underlies most protein annotation, yet many functions remain hidden beyond detectable homology

Indexed as

AutophagyCell CommunicationReceptors, G-Protein-CoupledAnimalsAutophagosomesbeta-ArrestinsG-Protein-Coupled Receptor KinasesHumansMembrane ProteinsMicrotubule-Associated ProteinsMicrotubulesSaccharomyces cerevisiaebeta-ArrestinsG-Protein-Coupled Receptor KinasesMAP1LC3B protein, humanMembrane ProteinsMicrotubule-Associated ProteinsReceptors, G-Protein-Coupled

Identifiers

PMID42717083
PMCPMC13581589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.