Evidence map›Paper›PMID 42717052›Full record

ArticleNature chemical biology2026

A sequence motif enables widespread use of noncanonical redox cofactors in natural enzymes.

Samer Saleh, Ning-Hsiang Hsu, Emma Luu, Vincent C Martin, Hans Jefferson C Ng, William B Black, Shiding Zhang, Jin-Kwang Kim, Banumathi Sankaran, Andre H T Tran and 4 more

Abstract read

PubMed Publisher

In one paragraph

Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Itaconation and Succination as Metabolite-Derived Cysteine Modifications in Inflammatory Signalling: Biochemical Mechanisms, Chemoproteomic Mapping, and Therapeutic Opportunities.Cell biochemistry and biophysics · 2026
Review
Symphony-Bind: Prediction of Protein Binding Sites for 11 Representative Small Molecules and Ions via Fine-Tuning Protein Language Models and Grouped Multi-Task Learning.ACS omega · 2026
Article
Reprogramming the Rossmann Fold Signature Motif Creates Orthogonal Redox Biocatalysts.bioRxiv : the preprint server for biology · 2025
Article

4 · The record

Corrections and comments

Update of
A Sequence Motif Enables Widespread Use of Non-Canonical Redox Cofactors in Natural Enzymes.2025

5 · Who and what money

Authors and funding

14 authors.

Samer Saleh *Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.

Ning-Hsiang Hsu *Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.

Emma LuuGenome Center, University of California, Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-0388-9330

Vincent C MartinDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.

Hans Jefferson C NgDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.

William B BlackDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.ORCID http://orcid.org/0009-0007-2851-9997

Shiding ZhangDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.ORCID http://orcid.org/0009-0003-3497-820X

Jin-Kwang KimDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.

Banumathi SankaranMolecular Biophysics and Integrated Bioimaging, Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-3266-8131

Andre H T TranDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.

Ryan L HayesDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.

Justin B SiegelGenome Center, University of California, Davis, Davis, CA, USA.

Feng QiaoDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA. qiao@uci.edu.ORCID http://orcid.org/0000-0002-1704-7257

Han LiDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA. han.li@uci.edu.ORCID http://orcid.org/0000-0002-6113-6433

Funding

Molecular Mechanisms of Telomere Length HomeostasisR35GM149572 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Feng Qiao · 2023 to 2026

$1.8M

DOE | Advanced Research Projects Agency - Energy (Advanced Research Projects Agency - Energy - U.S. Department of Energy) DE-AR0001508National Science Foundation (NSF) 1627539National Science Foundation (NSF) 1805510National Science Foundation (NSF) 1827246National Science Foundation (NSF) 2328145U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) 1R35GM153401U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01 GM 076324-11U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM149572

6 · The paper itself

Abstract

Noncanonical redox cofactors (NRCs) are low-cost alternatives to the natural redox cofactors nicotinamide adenine dinucleotide (NAD

Identifiers

PMID42717052

DOI10.1101/gr.849004

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.