Evidence map›Paper›PMID 42717047›Full record

ArticleSurgical endoscopy2026

Endoscopic ultrasound-guided angioembolization using cyanoacrylate for management of refractory non-variceal upper gastrointestinal bleeding.

Fei Liu, Zhenyun Gong, Jialiang Huang, Duanmin Hu, Guilian Cheng

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Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Fei Liu *Department of Gastroenterology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhenyun Gong *Department of Gastroenterology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Jialiang HuangDepartment of Gastroenterology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Duanmin HuDepartment of Gastroenterology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Guilian ChengDepartment of Gastroenterology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. 854235202@qq.com.

Funding

Major Project of Philosophy and Social Science Research in Colleges and Universities of Jiangsu Province DZXYJ202404
6 · The paper itself

Abstract

BACKGROUND AND STUDY

aimsRefractory non-variceal upper gastrointestinal bleeding (NVUGIB) remains a clinical challenge. Endoscopic ultrasound-guided angioembolization (EUS-A) may offer a salvage hemostatic approach, but evidence is limited. This study aimed to evaluate the efficacy and safety of EUS-A for management of refractory NVUGIB.

methodsTwenty-eight patients with NVUGIB who underwent EUS-A at The Second Affiliated Hospital of Soochow University from January 2023 to December 2025 were enrolled in this study. Endoscopic ultrasound-guided intravascular cyanoacrylate injection was carried out when patients had failed and/or were deemed unsuitable candidates for standard therapies. The data were retrospectively collected.

resultsA total of 28 patients underwent 30 EUS-A procedures. Among these, 8 cases were due to bleeding from benign lesions. The technical success rate was 100% (8/8; 95% CI, 0.63-1), 30-day rebleeding rate was 0% (0/8; 95% CI: 0-0.37), clinical success rate was 100% (8/8; 95% CI: 0.63-1), and bleeding-related mortality rate was 0% (0/8; 95% CI: 0-0.37). The 20 cases were due to bleeding from malignant lesions. The technical success rate was 100% (22/22; 95% CI: 0.85-1), 30-day rebleeding rate was 22.7% (5/22; 95% CI: 0.08-0.45), clinical success rate was 77.3% (17/22; 95% CI: 0.55-0.92), and bleeding-related mortality rate was 15.0% (3/20; 95% CI: 0.03-0.38). The overall technical success rate was 100% (30/30; 95% CI: 0.88-1), 30-day rebleeding rate was 16.7% (5/30; 95% CI: 0.06-0.35), clinical success rate was 83.3% (25/30; 95% CI: 0.65-0.94), and bleeding-related mortality rate was 10.7% (3/28; 95% CI: 0.02-0.28). No procedure-related complications such as perforation or ectopic embolism occurred.

conclusionEUS-A using cyanoacrylate may be a feasible alternative for select patients with NVUGIB who have failed or are unsuitable for standard therapies, particularly those with malignancy-related bleeding.

Indexed as

Cyanoacrylate injectionInterventional endoscopic ultrasoundRefractory GI bleeding

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.