Evidence map›Paper›PMID 42716945›Full record

ArticleNature communications2026

Peritoneal ovarian cancer growth in the omentum proceeds independently of mature adipocytes.

Rachel L Mintz, Jichang Han, Emily G Butka, Alexandre Gallerand, Shuai Gao, Ayoung Kim, Sarah Ning, Nicole K H Yiew, Mary Wohltmann, Galina Fedotova and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rachel L MintzDepartment of Biomedical Engineering, Washington University, St. Louis, MO, USA.
Jichang HanDepartment of Pathology and Immunology, Washington University, St. Louis, MO, USA.
Emily G ButkaVagelos Division of Biomedical and Biological Sciences, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-2615-3454
Alexandre GallerandDepartment of Pathology and Immunology, Washington University, St. Louis, MO, USA.
Shuai GaoDepartment of Pathology and Immunology, Washington University, St. Louis, MO, USA.
Ayoung KimDepartment of Pathology and Immunology, Washington University, St. Louis, MO, USA.
Sarah NingDepartment of Pathology and Immunology, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0009-0008-9052-0005
Nicole K H YiewDepartment of Pathology and Immunology, Washington University, St. Louis, MO, USA.
Mary WohltmannDepartment of Pathology and Immunology, Washington University, St. Louis, MO, USA.
Galina FedotovaDepartment of Pathology and Immunology, Washington University, St. Louis, MO, USA.
Wei ZouDepartment of Pathology and Immunology, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-8081-268X
Nan ZhangImmunology, Microenvironment and Metastasis Program, Ellen and Ronald Caplan Cancer Center, The Wistar Institute, Philadelphia, PA, USA.
Samantha A MorrisDepartment of Genetics and Developmental Biology, Washington University, St. Louis, MO, USA.
Bernd H ZinselmeyerDepartment of Pathology and Immunology, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-4172-6767
Gwendalyn J RandolphDepartment of Pathology and Immunology, Washington University, St. Louis, MO, USA. gjrandolph@wustl.edu.ORCID http://orcid.org/0000-0001-9045-1195

Funding

Differentiation/migratory fate of monocyte-derived cellsR01AI049653 · NIAID · WASHINGTON UNIVERSITY · PI Gwendalyn J Randolph · 2000 to 2026
$4.6M
DIFFERENTIATION AND FUNCTION OF MONOCYTES AND MACROPHAGESR37AI049653 · NIAID · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2016 to 2025
$4.3M
Deciphering the role of tumor-macrophage crosstalk during metastatic dissemination to the peritoneumK00CA264434 · NCI · WASHINGTON UNIVERSITY · PI HAN, JICHANG · 2022 to 2025
$388k
Dynamics and function of peritoneal myeloid cells during colorectal cancer peritoneal dissemination and implications for immunotherapyK99CA300889 · NCI · WASHINGTON UNIVERSITY · PI Jichang Han · 2025 to 2026
$334k
Mechanisms Underlying the Omental Support of Ovarian Cancer Peritoneal MetastasisF30CA281124 · NCI · WASHINGTON UNIVERSITY · PI Rachel Mintz · 2023 to 2026
$216k
NCI NIH HHS F30 CA281124NCI NIH HHS K00 CA264434NCI NIH HHS K99 CA300889NIAID NIH HHS R01 AI049653NIAID NIH HHS R37 AI049653U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI049653
6 · The paper itself

Abstract

The omentum, a specialized adipose tissue within the peritoneum, is a primary niche of ovarian cancer dissemination. Omental adipocytes are widely thought to promote tumor growth by supplying lipids, supported in part by studies using global FABP4 deficiency. Here, we directly test whether mature adipocytes are required for peritoneal ovarian cancer growth using mice congenitally lacking mature adipocytes within the peritoneal cavity, including the omentum. Across several ovarian cancer models (ID8p53

Indexed as

AdipocytesOmentumOvarian NeoplasmsPeritoneal NeoplasmsAnimalsEndothelial CellsFatty Acid-Binding ProteinsFemaleHumansMiceMice, Inbred C57BLMice, KnockoutFABP4 protein, humanFabp4 protein, mouseFatty Acid-Binding Proteins

Identifiers

PMID42716945
PMCPMC13558732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.