ArticleNature communications2026
Multiple-layer mesh from electrospinnable amyloid‑like protein and their application in treating oral ulcer.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Oral ulcers significantly impair quality of life due to prolonged severe pain caused by delayed healing. The moist, dynamic, microorganism‑rich environment hinders natural scab formation and ordinary patch adhesion, limiting therapeutic outcomes. Inspired by bioadhesion, we propose an unfolding‑stabilization strategy to overcome globular protein electrospinning limitations and construct a multifunctional patch. Water triggers a conformational transition to an amyloid‑like β‑sheet interface that disrupts the hydration layer for initial wet adhesion, while Carbomer-mucin interactions further enhance retention. This synergy gives adhesion strength 6-50 times that of commercial products, enabling sustained attachment in complex oral environments for effective ulcer protection. Glycyrrhetinic acid provides local antibacterial and anti‑inflammatory effects. In a rat model, the patch improves healing by 75% over the best commercial control. It also matches the mucosal modulus, while being steroid‑free, biodegradable, and biocompatible. By integrating electrospinning with amyloid‑mediated adhesion, this work offers a scalable strategy for engineering multifunctional wet biointerfaces.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.