Evidence map›Paper›PMID 42716922›Full record

ArticleNature communications2026

Prefrontal-raphe-habenular circuit drives fear memory recall and updating.

Boldizsár Zsolt Balog, Albert M Barth, Krisztián Zichó, Abel Major, Zsuzsanna Bardóczi, János Brunner, Charlotte Seng, Márta Jelitai, Katalin E Sos, Réka Z Sebestény and 11 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Boldizsár Zsolt Balog *Systems & Integrative Neuroscience Research Group, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.ORCID http://orcid.org/0009-0003-4968-2321
Albert M Barth *Systems & Integrative Neuroscience Research Group, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.
Krisztián Zichó *Systems & Integrative Neuroscience Research Group, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.ORCID http://orcid.org/0000-0002-7970-4806
Abel Major *Systems & Integrative Neuroscience Research Group, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.ORCID http://orcid.org/0000-0002-2620-8753
Zsuzsanna BardócziSystems & Integrative Neuroscience Research Group, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.
János BrunnerLaboratory of Cellular Neuropharmacology, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.ORCID http://orcid.org/0000-0001-9395-2446
Charlotte SengLaboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich, Switzerland.ORCID http://orcid.org/0009-0005-6827-5371
Márta JelitaiLaboratory of Subcortical Modulation, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.
Katalin E SosSystems & Integrative Neuroscience Research Group, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.ORCID http://orcid.org/0000-0002-2957-2593
Réka Z SebesténySystems & Integrative Neuroscience Research Group, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.ORCID http://orcid.org/0000-0003-2930-1096
András SzőnyiLaboratory for Cellular Mechanisms of Learning and Memory, Friedrich Miescher Institute, Basel, Switzerland.
Nikolas KaralisLaboratory for Cellular Mechanisms of Learning and Memory, Friedrich Miescher Institute, Basel, Switzerland.
Áron OroszSystems & Integrative Neuroscience Research Group, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.
Eszter SiposLaboratory of Cellular Neuropharmacology, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.
Erik MisákSystems & Integrative Neuroscience Research Group, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.ORCID http://orcid.org/0009-0000-2036-3085
György CsereyFaculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary.ORCID http://orcid.org/0000-0002-6836-1502
Andreas LüthiLaboratory for Cellular Mechanisms of Learning and Memory, Friedrich Miescher Institute, Basel, Switzerland.ORCID http://orcid.org/0000-0002-1859-4252
Viktor VargaLaboratory of Subcortical Modulation, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.ORCID http://orcid.org/0000-0002-1665-969X
Csaba FöldyLaboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0001-8709-8490
János SzabadicsLaboratory of Cellular Neuropharmacology, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.
Gábor NyiriSystems & Integrative Neuroscience Research Group, HUN-REN Institute of Experimental Medicine, Budapest, Hungary. nyiri.gabor@koki.hun-ren.hu.ORCID http://orcid.org/0000-0002-4247-0356

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fear memory recall is a vital defensive response, yet its underlying neuronal mechanism remains incompletely understood. Here, we identify an effective fear recall pathway. We found that hippocampal and amygdalar memory centers directly target a group of medial prefrontal cortex (mPFC) neurons, which are necessary for fear recall and directly target vesicular glutamate transporter 2 (vGluT2)-expressing neurons in the pontine median raphe region (MRR

Indexed as

FearHabenulaMental RecallPrefrontal CortexAmygdalaAnimalsHippocampusMaleMemoryMiceMice, Inbred C57BLNeural PathwaysNeuronsVesicular Glutamate Transport Protein 2Slc17a6 protein, mouseVesicular Glutamate Transport Protein 2

Identifiers

PMID42716922
PMCPMC13558683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.