Evidence map›Paper›PMID 42716825›Full record

ArticleTrends in biotechnology2026

Engineering biosensors to enhance monoterpene indole alkaloid production in yeast.

Maxence Holtz, Simon D'Oelsnitz, Cecília Castellví Domingo, Niklas G Madsen, Mars Yu Hong, Jonathan Asmund Arnesen, Aafke C A van Aalst, Samantha de Haan, Christopher K Weingarten, Ditte H Welner and 4 more

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Article in Trends in biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Maxence HoltzThe Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition, Technical University of Denmark, Kongens Lyngby, Denmark.
Simon D'OelsnitzSynthetic Biology HIVE, Harvard Medical School, Boston, MA, USA.
Cecília Castellví DomingoThe Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition, Technical University of Denmark, Kongens Lyngby, Denmark.
Niklas G MadsenThe Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition, Technical University of Denmark, Kongens Lyngby, Denmark.
Mars Yu HongThe University of Texas at Austin, Austin, TX, USA.
Jonathan Asmund ArnesenThe Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition, Technical University of Denmark, Kongens Lyngby, Denmark.
Aafke C A van AalstThe Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition, Technical University of Denmark, Kongens Lyngby, Denmark.
Samantha de HaanThe Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition, Technical University of Denmark, Kongens Lyngby, Denmark.
Christopher K WeingartenThe Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition, Technical University of Denmark, Kongens Lyngby, Denmark.
Ditte H WelnerThe Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition, Technical University of Denmark, Kongens Lyngby, Denmark.
Pamela A SilverSynthetic Biology HIVE, Harvard Medical School, Boston, MA, USA.
Yan Jessie ZhangThe University of Texas at Austin, Austin, TX, USA.
Michael K JensenBiomia ApS, Copenhagen, Denmark. Electronic address: mkj@biomia.com.
Carlos G Acevedo-RochaThe Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition, Technical University of Denmark, Kongens Lyngby, Denmark. Electronic address: cargac@dtu.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monoterpene indole alkaloids (MIAs) are medicinally valuable plant natural products, but their scarcity and structural complexity hinder conventional production. Microbial cell factories offer a sustainable alternative, although optimization of their long biosynthetic pathways is constrained by costly, low-throughput analytics. In this article, we evolved the promiscuous bacterial transcription factor RamR to detect five MIAs, obtaining sensitive and selective biosensor variants with EC

Indexed as

biosensordirected evolutionmetabolic engineeringmonoterpene indole alkaloidsRamRsynthetic biology

Identifiers

PMID42716825

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.