SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2026
Normal age-related decline in forced vital capacity: a systematic review and meta-analysis.
Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
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Abstract
Lung function peaks in early adulthood and declines thereafter, even without respiratory disease. Differentiating physiological ageing from pathological trajectories is critical for diagnosis, prognostication and interpretation of clinical trial end-points, particularly in interstitial lung diseases where attenuation of forced vital capacity (FVC) decline is a primary outcome in most trials. Without a benchmark for expected ageing, it is difficult to determine whether therapy preserves lung function by preventing FVC loss or mirrors natural trajectories. We conducted a systematic review and meta-analysis of longitudinal evidence on age-related FVC changes among adults without lung disease. A search of major databases and conference proceedings identified 7160 citations; 50 publications representing 35 cohorts and over 365 000 participants met eligibility criteria. Follow-up ranged from three to 35 years, with three to 12 spirometric assessments per participant. Over five decades of research, a consistent pattern of decline after early adulthood was evident, but estimates varied widely (10-80 mL·year
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