ArticleChirality2026
Mechanistic Insights Into Synephrine Isomerization Under Acidic and Neutral Conditions: A Combined Kinetic, Thermodynamic, and Quantum Chemical Approach.
Article in Chirality, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Synephrine is a chiral compound that exists as two enantiomers, the (R)- and (S)-forms. The present study investigated the effects of pH and heating conditions on the isomerization of synephrine. Each enantiomer was quantified after FMOC derivatization using chiral liquid chromatography with UV detection (chiral-LC/UV). When (R)-synephrine was incubated under acidic or neutral conditions at elevated temperatures, isomerization was promoted in a temperature-dependent manner under both conditions. The isomerization rate under the acidic condition was approximately 10- to 40-fold higher than that under the neutral condition, and the time-dependent progression followed pseudo-first-order kinetics under both conditions. Analysis of physicochemical parameters, including the activation entropy (ΔS
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