ArticleJournal of agricultural and food chemistry2026
In Vitro Evidence of α-Linolenic Acid Ethyl Ester Hydrolysis and Transesterification in the Gastrointestinal Tract in the Presence of Acylglycerols.
Article in Journal of agricultural and food chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Omega-3 polyunsaturated fatty acids (n-3 PUFA), such as α-linolenic acid (ALA), are crucial for human health. Although n-3 PUFAs in food are mainly in triacylglycerol (TAG) form, they are often provided as ethyl esters (EE) in supplements. Previous research has demonstrated improved postprandial bioavailability of n-3 PUFAs in the EE form when coingested with fat, potentially due to transesterification during digestion. To shed light on the bioavailability improvement, this study investigated the influence of triolein and 2-monoolein on the digestion of ALA-EE using an in vitro model, employing 1H NMR spectroscopy and liquid chromatography combined with mass spectrometry. ALA-EE hydrolysis increased from 6.6 to 22-29% with acylglycerols, reaching 55.8% after longer incubation with 2-monoolein. Transesterification of ALA in acylglycerols was observed, especially after incubation with 2-monoolein, but its correlation with ALA-EE hydrolysis remained ambiguous. Therefore, the bioavailability improvements were attributed to the facilitating effect of TAG lipolysis products on ALA release.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.