Evidence map›Paper›PMID 42715906›Full record

ArticleClinics (Sao Paulo, Brazil)2026

Association between serum 25-hydroxyvitamin D levels and bilateral vestibulopathy: A case-control study.

Dongxiao Zhou, Junjie Guo, Xiaoqiu Liang, Junyu Wu, Zhihui Zheng, Haiwei Huang, Weiwei Qi, Zhezhi Deng

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Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Dongxiao ZhouDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, China.
Junjie GuoDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, China.
Xiaoqiu LiangDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, China.
Junyu WuDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, China.
Zhihui ZhengDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, China.
Haiwei HuangDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, China.
Weiwei QiDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, China. Electronic address: qiweiwei3@mail.sysu.edu.cn.
Zhezhi DengDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, China. Electronic address: dengzhzh5@mail.sysu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe etiology of Bilateral Vestibulopathy (BVP) is complex. Given the close association between vitamin D and various vestibular disorders, including benign paroxysmal positional vertigo and vestibular neuritis, this study aims to investigate the relationship between serum vitamin D levels and BVP.

methodsThis single-center retrospective case-control study included 35 patients with BVP and 70 age- and sex-matched healthy controls (HC). Demographic information, clinical data, including 25-Hydroxyvitamin D (25(OH)D) levels, and vestibular assessment results were collected.

resultsSerum 25(OH)D levels were significantly lower in the BVP group than in the HC group (18.58±5.80 vs. 24.25±5.91 ng/mL, p < 0.001). Insufficient or deficient vitamin D levels were observed in 97.14% of patients in the BVP group (deficiency, 60.00%; insufficiency, 37.14%). No significant association was found between vitamin D insufficiency or deficiency and the disease duration, season of visit, residential latitude, or underlying medical conditions in patients with BVP. Binary logistic regression analysis showed that serum 25(OH)D levels were associated with BVP, with an odds ratio of 0.846 (95% CI 0.765-0.935; p = 0.001).

conclusionSerum 25(OH)D levels were significantly lower in patients with BVP than in HC, suggesting an association between vitamin D insufficiency/deficiency and BVP.

Indexed as

25-hydroxyvitamin DBilateral vestibulopathyVestibular disordersVitamin D deficiency

Identifiers

PMID42715906
PMCPMC13573686

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.