Evidence map›Paper›PMID 42715556›Full record

ArticlePhysiological genomics2026

Bacterial serine protease EspP induces differentiation and expansion of enteroendocrine cells in human colonoids.

Myranda N Thompson, Ruixuan Liu, Cristina N Coffman, Allison M Kilpatrick, Lito L Appell, Roger Atanga, Julie G In

Abstract read
In one paragraph

Article in Physiological genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Myranda N ThompsonDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States.ORCID 0009-0007-6332-5768
Ruixuan LiuDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States.ORCID 0009-0007-4962-2109
Cristina N CoffmanDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States.ORCID 0000-0001-9114-6467
Allison M KilpatrickDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States.
Lito L AppellDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States.ORCID 0000-0002-9965-7613
Roger AtangaDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States.ORCID 0009-0006-7644-6326
Julie G InDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States.ORCID 0000-0001-7075-3444

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Monica Rosas Lemus · 2017 to 2026
$24.9M
Biology of Infectious Diseases &InflammationT32AI007538 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Michelle A Ozbun · 1998 to 2026
$5.2M
Initiative to Maximize Student Diversity at the University of New Mexico Health Sciences Center 2021T32GM144834 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Judy Lin Cannon, Bryce C Chackerian · 2022 to 2026
$2.7M
Molecular Basis of Microbial PathogenesisT32AI007537 · NIAID · UNIVERSITY OF COLORADO DENVER · PI HOLMES, RANDALL K · 1998 to 2007
$1.3M
Heavy metals exposure regulates secretory lineage in intestinal injuryR01ES034400 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Julie Goeun In · 2024 to 2026
$1.1M
Human Enteroids as a Model of Host-EHEC InteractionsK01DK106323 · NIDDK · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI IN, JULIE GOEUN · 2016 to 2020
$711k
AGA Research Foundation (American Gastroenterological Association AGA) AGA SURFHHS | National Institutes of Health (NIH) K01DK106323HHS | National Institutes of Health (NIH) P20GM121176HHS | National Institutes of Health (NIH) R01ES034400HHS | National Institutes of Health (NIH) T32AI007537HHS | National Institutes of Health (NIH) T32GM144834NCI NIH HHS P30 CA118100NIAID NIH HHS T32 AI007537NIAID NIH HHS T32 AI007538NIDDK NIH HHS K01 DK106323NIEHS NIH HHS R01 ES034400NIGMS NIH HHS P20 GM121176NIGMS NIH HHS T32 GM144834
6 · The paper itself

Abstract

Extracellular serine protease, plasmid-encoded (EspP) is a potent serine protease that functions as a cytotoxin and is secreted by enterohemorrhagic

Indexed as

Cell DifferentiationColonEnteroendocrine CellsEscherichia coli ProteinsOrganoidsSerine ProteasesCell ProliferationHumansTranscriptomeEscherichia coli ProteinsSerine Proteasesbacterial serine proteaseenteroendocrine cellsenterohemorrhagic E. coliintestinal organoidssecretory lineage differentiation

Identifiers

PMID42715556
PMCPMC13637730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.