Trial reportScience translational medicine2026
Reprogramming engineered autologous T cells to overcome resistance in patients with Merkel cell carcinoma.
Yuta Asano, Joshua R Veatch, Cheng-Jung Sung, Tzu-Hao Tang, Francesco Mazziotta, Seiji Natsuki, Megan McAfee, Jakob Bakhtiari, Bo Lee, Lauren Martin and 24 more
Abstract readClinical Trial, Phase IClinical Trial, Phase II
In one paragraphTrial report in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from itWhat it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
34 authors.
Yuta AsanoTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-4720-2238 Joshua R VeatchTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-6543-9255 Cheng-Jung SungTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0001-7858-8308 Tzu-Hao TangTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0009-0009-2596-1872 Francesco MazziottaTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-6126-8719 Seiji NatsukiTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Megan McAfeeTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Jakob BakhtiariTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Bo LeeTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Lauren MartinTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0003-3894-3162 Alessandro RizziTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0009-0001-1963-0884 Tianzi ZhangTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0003-3475-3564 Colton W SmithTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0003-3669-8327 Kelly G PaulsonTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-0033-3708 Thomas M SchmittTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-0736-4195 Evan W NewellDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-2889-243X Anna E ElzVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-7718-3015 Daniel G ChenTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0001-6660-6257 Yapeng SuTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-6305-8467 Heather H GustafsonDepartment of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-5484-5821 Cecilia C S YeungTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0001-6799-2022 Brandon SeatonTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0009-0004-5397-4631 Daniel HunterTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0009-0009-0124-1918 David M KoelleDepartment of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0003-1255-9023 Shailender BhatiaDepartment of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-3816-2238 Evan T HallDepartment of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-0305-7745 Valentin VoilletVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-5751-3881 Jianhong CaoShared Resources, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Ted GooleyTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Philip D GreenbergTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Raphael GottardoBiomedical Data Science Center, Centre Hospitalier Universitaire Vaudois, 1010 Lausanne, Switzerland.ORCID 0000-0002-3867-0232 Shannon K OdaDepartment of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-2844-1372 Paul NghiemTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0003-2784-963X Aude G ChapuisTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-9574-5448 Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MUnderstand & overcome resistance to PD-1P01CA225517 · NCI · UNIVERSITY OF WASHINGTON · PI Cecilia C Yeung · 2019 to 2026
$22.7MNCI NIH HHS P01 CA225517NCI NIH HHS P30 CA015704
6 · The paper itselfAbstract
Immune checkpoint inhibitors (ICIs) have transformed Merkel cell carcinoma (MCC) outcomes, but most patients with MCC develop resistance. We identified T cell receptor (TCR)
Indexed as
Carcinoma, Merkel CellDrug Resistance, NeoplasmT-LymphocytesAnimalsCell Line, TumorFemaleHumansMaleMerkel cell polyomavirusMiceReceptors, Antigen, T-CellReceptors, Antigen, T-Cell
Identifiers
PMID42715345
PMCPMC13644984
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