Evidence map›Paper›PMID 42715345›Full record

Trial reportScience translational medicine2026

Reprogramming engineered autologous T cells to overcome resistance in patients with Merkel cell carcinoma.

Yuta Asano, Joshua R Veatch, Cheng-Jung Sung, Tzu-Hao Tang, Francesco Mazziotta, Seiji Natsuki, Megan McAfee, Jakob Bakhtiari, Bo Lee, Lauren Martin and 24 more

Abstract readClinical Trial, Phase IClinical Trial, Phase II
In one paragraph

Trial report in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Yuta AsanoTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-4720-2238
Joshua R VeatchTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-6543-9255
Cheng-Jung SungTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0001-7858-8308
Tzu-Hao TangTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0009-0009-2596-1872
Francesco MazziottaTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-6126-8719
Seiji NatsukiTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Megan McAfeeTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Jakob BakhtiariTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Bo LeeTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Lauren MartinTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0003-3894-3162
Alessandro RizziTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0009-0001-1963-0884
Tianzi ZhangTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0003-3475-3564
Colton W SmithTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0003-3669-8327
Kelly G PaulsonTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-0033-3708
Thomas M SchmittTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-0736-4195
Evan W NewellDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-2889-243X
Anna E ElzVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-7718-3015
Daniel G ChenTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0001-6660-6257
Yapeng SuTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-6305-8467
Heather H GustafsonDepartment of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-5484-5821
Cecilia C S YeungTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0001-6799-2022
Brandon SeatonTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0009-0004-5397-4631
Daniel HunterTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0009-0009-0124-1918
David M KoelleDepartment of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0003-1255-9023
Shailender BhatiaDepartment of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-3816-2238
Evan T HallDepartment of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-0305-7745
Valentin VoilletVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-5751-3881
Jianhong CaoShared Resources, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Ted GooleyTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Philip D GreenbergTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Raphael GottardoBiomedical Data Science Center, Centre Hospitalier Universitaire Vaudois, 1010 Lausanne, Switzerland.ORCID 0000-0002-3867-0232
Shannon K OdaDepartment of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-2844-1372
Paul NghiemTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0003-2784-963X
Aude G ChapuisTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-9574-5448

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Understand & overcome resistance to PD-1P01CA225517 · NCI · UNIVERSITY OF WASHINGTON · PI Cecilia C Yeung · 2019 to 2026
$22.7M
NCI NIH HHS P01 CA225517NCI NIH HHS P30 CA015704
6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) have transformed Merkel cell carcinoma (MCC) outcomes, but most patients with MCC develop resistance. We identified T cell receptor (TCR)

Indexed as

Carcinoma, Merkel CellDrug Resistance, NeoplasmT-LymphocytesAnimalsCell Line, TumorFemaleHumansMaleMerkel cell polyomavirusMiceReceptors, Antigen, T-CellReceptors, Antigen, T-Cell

Identifiers

PMID42715345
PMCPMC13644984

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.