Evidence map›Paper›PMID 42715338›Full record

ArticleScience advances2026

Dysregulated m

Geun-Woo D Kim, Dahee Choi, Soo-Young Kim, Haengdueng Jeong, Geon Kang, So Jung Eom, Sangkyeong Eom, Jinyoung Park, Hye-Sook Lee, Insook Yang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Geun-Woo D KimDivision of Life Sciences, Korea University, Seoul 02841, Korea.ORCID 0000-0003-0161-6707
Dahee ChoiDivision of Life Sciences, Korea University, Seoul 02841, Korea.ORCID 0000-0001-7672-461X
Soo-Young KimDivision of Life Sciences, Korea University, Seoul 02841, Korea.ORCID 0009-0007-3345-9669
Haengdueng JeongDepartment of Molecular and Life Science, Hanyang University, Ansan, Korea.ORCID 0000-0002-9218-7372
Geon KangDivision of Life Sciences, Korea University, Seoul 02841, Korea.ORCID 0009-0007-1635-0012
So Jung EomDivision of Life Sciences, Korea University, Seoul 02841, Korea.
Sangkyeong EomDivision of Life Sciences, Korea University, Seoul 02841, Korea.ORCID 0000-0001-9716-4498
Jinyoung ParkDivision of Life Sciences, Korea University, Seoul 02841, Korea.ORCID 0000-0001-6579-4356
Hye-Sook LeeDivision of Life Sciences, Korea University, Seoul 02841, Korea.
Insook YangYonsei Biomedical Research Institute, Yonsei University College of Medicine, Seoul 03760, Korea.ORCID 0009-0006-3909-9580
Je Kyung SungKorea Model Animal Priority Center, Seoul National University, Seoul 08826, Korea.ORCID 0000-0003-1177-6958
Ki Taek NamDepartment of Biomedical Sciences, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03760, Korea.ORCID 0000-0001-5292-1280
Young Nyun ParkDepartment of Pathology, Graduate School of Medical Science, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03760, Korea.ORCID 0000-0003-0357-7967
Sung Wook ChiDivision of Life Sciences, Korea University, Seoul 02841, Korea.ORCID 0000-0002-8035-8242
Seung-Hoi KooDivision of Life Sciences, Korea University, Seoul 02841, Korea.ORCID 0000-0001-8769-2879

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) originates from premalignant disease-associated hepatocytes (daHeps) that emerge during the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) to metabolic dysfunction-associated steatohepatitis (MASH). As daHeps are compensatorily primed by metabolic stress, we reproduced the accelerated progression of MASLD-associated HCC in mice by phenocopying the decreased expression of a metabolic regulator, protein arginine methyltransferase 1 (PRMT1). In

Indexed as

AdenosineArginineCarcinoma, HepatocellularFatty LiverLiver NeoplasmsPrecancerous ConditionsProtein-Arginine N-MethyltransferasesAnimalsEpitranscriptomeHumansKelch-Like ECH-Associated Protein 1MethylationMiceMice, KnockoutNF-E2-Related Factor 2Repressor ProteinsAdenosineArginineKeap1 protein, mouseKelch-Like ECH-Associated Protein 1Nfe2l2 protein, mouseNF-E2-Related Factor 2N-methyladenosinePrmt1 protein, mousePRMT6 protein, mouseProtein-Arginine N-MethyltransferasesRepressor Proteins

Identifiers

PMID42715338
PMCPMC13557090

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.