A direct protein bridge connects the ds and ds-ss junction telomeric DNA segments in

Valerie M Tesmer, Nils J Lambacher, Io Yamamoto, Jayakrishnan Nandakumar, Hiroki Shibuya

Abstract read

In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Valerie M TesmerDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-7445-8407

Nils J LambacherDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.ORCID 0009-0001-8512-1519

Io YamamotoDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.ORCID 0009-0004-9862-4627

Jayakrishnan NandakumarDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-9146-2785

Hiroki ShibuyaDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-3400-0741

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026

$7.5M

Molecular mechanisms of intersecting human telomeric functionsR35GM148276 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jayakrishnan Nandakumar · 2023 to 2026

$1.6M

NIGMS NIH HHS R35 GM148276NIH HHS P40 OD010440

6 · The paper itself

Abstract

The six-protein shelterin complex safeguards mammalian chromosome ends; however, its intricate protein-protein and protein-DNA interactions complicate biochemical dissection. The

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsDNA-Binding ProteinsTelomereTelomere-Binding ProteinsAnimalsDNA, Single-StrandedModels, MolecularProtein BindingShelterin ComplexCaenorhabditis elegans ProteinsDNA-Binding ProteinsDNA, Single-StrandedPOT-1 protein, C elegansPOT-2 protein, C elegansShelterin ComplexTelomere-Binding Proteins

Identifiers

PMID42715327

DOI10.1126/sciadv.aeg8967

PMCPMC13557083

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.