Evidence map›Paper›PMID 42715174›Full record

ArticlePloS one2026

miR-191 affects skeletal muscle differentiation by regulating Wwp1 in mouse myoblasts.

Wenhua Pu, Meimei Zhang, Siman Guo, Xiang Bao, Wenjia Cui, Chuncheng Liu

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Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Wenhua PuInner Mongolia Key Laboratory of Life Health and Bioinformatics, School of Life Science and Technology, Inner Mongolia University of Science & Technology, Baotou, China.
Meimei ZhangDepartment of Geriatrics, Ordos Central Hospital, Ordos, Inner Mongolia, China.
Siman GuoInner Mongolia Key Laboratory of Life Health and Bioinformatics, School of Life Science and Technology, Inner Mongolia University of Science & Technology, Baotou, China.
Xiang BaoDepartment of Geriatrics, Ordos Central Hospital, Ordos, Inner Mongolia, China.
Wenjia CuiInner Mongolia Key Laboratory of Life Health and Bioinformatics, School of Life Science and Technology, Inner Mongolia University of Science & Technology, Baotou, China.
Chuncheng LiuInner Mongolia Key Laboratory of Life Health and Bioinformatics, School of Life Science and Technology, Inner Mongolia University of Science & Technology, Baotou, China.ORCID https://orcid.org/0000-0001-5451-5550

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle atrophy is a key complication of various diseases, such as chronic obstructive pulmonary disease (COPD) and cancer. The mechanisms by which these diseases affect skeletal muscle metabolism need to be deeply explored. By analyzing the miRNA expression profiles in the plasma of patients with COPD, we found that miR-191 expression was significantly altered and it may influence skeletal muscle metabolism by regulating ubiquitination and the mTOR pathway. Using a mouse model of skeletal muscle injury induced by cardiotoxin, we found that miR-191 and Wwp1 showed a dynamic negative correlation in injury repair. Transfection with miR-191 mimics significantly inhibited the expression of myogenic regulatory factor Myog and differentiation markers Myh1/7/8, while downregulating key genes in the mTOR pathway. Molecular mechanism studies showed that miR-191 could directly act on the 3' untranslated region of the Wwp1 gene to inhibit its expression. This study reveals the important role of the miR-191/Wwp1 axis in skeletal muscle differentiation and provides a novel theoretical basis for research on muscle atrophy induced by COPD, cancer cachexia, and other diseases.

Indexed as

Cell DifferentiationMicroRNAsMuscle, SkeletalMyoblastsUbiquitin-Protein Ligases3' Untranslated RegionsAnimalsGene Expression RegulationHumansMaleMiceMuscular AtrophyPulmonary Disease, Chronic ObstructiveSignal TransductionTOR Serine-Threonine Kinases3' Untranslated RegionsMicroRNAsTOR Serine-Threonine KinasesUbiquitin-Protein Ligases

Identifiers

PMID42715174
PMCPMC13557400

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.