ArticleObesity facts2026
Ethanol Pharmacokinetics and Alcohol-Related Effects after One-Anastomosis Gastric Bypass: A Prospective before-after Study.
Article in Obesity facts, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionMetabolic-bariatric surgery is associated with altered ethanol pharmacokinetics and increased alcohol-related risk. While these changes have been described after Roux-en-Y gastric bypass and sleeve gastrectomy, data regarding one-anastomosis gastric bypass (OAGB) have not been reported. This exploratory study evaluated changes in alcohol absorption, elimination, and subjective intoxication following OAGB.
methodsIn this prospective before-after interventional study, adults undergoing OAGB were assessed preoperatively and at 1 month and 4 months postoperatively. At each visit, participants ingested 200 mL of red wine (13.5% alcohol by volume; ∼21.3 g ethanol). Breath alcohol concentration (BrAC) was measured at fixed time points over 2 h using a calibrated breathalyzer. Pharmacokinetic parameters, including maximum concentration (C
resultsTen participants (mean age 42 ± 12.8 years; 60% female) were included in this study. Mean C
conclusionOAGB alters ethanol pharmacokinetics, leading to higher peak alcohol concentrations, increased systemic exposure, and enhanced subjective alcohol effects. Even modest alcohol intake may potentially lead to high BrAC levels after OAGB, reflecting the need for clinician-led patient education and advice on safer alcohol use after surgery. Given the small sample size, participant attrition, and short postoperative observation period, the study findings should be interpreted with caution.
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