Protocol for mapping frequency-specific information transfer between cortical areas using ECoG and Granger causality.

Xiangsheng Zeng, Tao Zhou, Chengpeng Li, Isao Hasegawa, Hisashi Tanigawa

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Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Xiangsheng ZengSchool of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China; Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China.

Tao ZhouSchool of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.

Chengpeng LiSchool of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China; Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China.

Isao HasegawaDepartment of Physiology, Niigata University School of Medical and Dental Sciences, Niigata, Japan.

Hisashi TanigawaSchool of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China; Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China; National Key Laboratory of Brain and Computer Intelligence, Zhejiang University, Hangzhou 310058, China; MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310012, China; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou 310058, China. Electronic address: hisashi.q@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This protocol details the application of Granger causality (GC) analysis to primate electrocorticography (ECoG) data to map frequency-specific information transfer. We describe steps for computing pairwise GC and generating spatial GC maps, including differential maps to isolate task-specific activity. We then explain how to perform hierarchical clustering on GC patterns to identify and visualize the spatial distribution of functional electrode clusters, revealing the organization of information flow. For complete details on the use and execution of this protocol, please refer to Zhou et al.

Indexed as

BehaviorCognitive NeuroscienceNeuroscience

Identifiers

PMID42715105

DOI10.1016/j.xpro.2026.104833

PMCPMC13584030

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.