ArticleProceedings of the National Academy of Sciences of the United States of America2026
Gating crosstalk in potassium channels.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Gating crosstalk in potassium channels.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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3 authors.
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Abstract
Ion permeation through potassium channels is regulated by multiple gates. In particular, conformational changes in the central cavity (the activation gate) can propagate to the selectivity filter (an inactivation gate), resulting in altered filter structure and suppression of ion permeation. Despite extensive studies, the detailed mechanism underlying the allosteric coupling between these two gating elements is not entirely understood. In this work, we investigate this question using extensive molecular dynamics (MD) simulations of multiple channels. We show that opening and closing of the central cavity simultaneously modulate cavity hydration level and the width of the selectivity filter entrance. Both structural features influence ion permeation rate. Cavity hydration reshapes the free energy of K
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