Evidence map›Paper›PMID 42714969›Full record

ArticlePsycho-oncology2026

Young Women With Pancreatic Cancer: A High-Risk Group for Demoralization.

Abrahm Levi, Aryan Nasr, Yujie Cui, Anser A Abbas, Tara T Arouchian, Andrew L Coveler, Tracey L Pierce, Brian T Anderson, Eric Collisson, John Davelaar and 5 more

Abstract read
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In one paragraph

Article in Psycho-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Abrahm LeviCedars-Sinai Medical Center, Los Angeles, California, USA.ORCID https://orcid.org/0009-0005-3074-6166
Aryan NasrCedars-Sinai Medical Center, Los Angeles, California, USA.ORCID https://orcid.org/0009-0000-0344-2929
Yujie CuiCedars-Sinai Medical Center, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-8254-6474
Anser A AbbasCedars-Sinai Medical Center, Los Angeles, California, USA.
Tara T ArouchianCedars-Sinai Medical Center, Los Angeles, California, USA.ORCID https://orcid.org/0009-0004-8310-1997
Andrew L CovelerFred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID https://orcid.org/0000-0003-1710-5637
Tracey L PierceFred Hutchinson Cancer Center, Seattle, Washington, USA.
Brian T AndersonUniversity of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-5023-660X
Eric CollissonFred Hutchinson Cancer Center, Seattle, Washington, USA.
John DavelaarCedars-Sinai Medical Center, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-2426-6749
Simon K LoCedars-Sinai Medical Center, Los Angeles, California, USA.
Srinivas GaddamCedars-Sinai Medical Center, Los Angeles, California, USA.
Jun GongCedars-Sinai Medical Center, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-8713-1406
Arsen OsipovCedars-Sinai Medical Center, Los Angeles, California, USA.
Andrew E HendifarCedars-Sinai Medical Center, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-2079-9177

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDemoralization is a maladaptive coping response to stressful situations, characterized by thoughts of hopelessness, helplessness, and loss of meaning and purpose. Demoralization is clinically measurable using the Demoralization Scale 2 (DS-II). Pancreatic cancer (PC) patients, who carry a notoriously poor prognosis, are hypothesized to be at higher risk of demoralization.

aimsThis study uses the DS-II to gauge the impact of demoralization in PC patients compared to a heterogenous cancer population and establish its relation to depression.

methodsPatients completed the DS-II, PHQ-9, and a demographic survey. The mean DS-II score of PC patients was compared with that of a previously published heterogenous cancer cohort reported by Ignatius et al. using a one-sample t-test. The univariable association between DS-II scores and PHQ-9 scores was examined using linear regression models.

resultsOf the 206 patients enrolled in the study, 47% were women and the mean age was 67 ± 10 years. The mean DS-II total score was 4.9 ± 5.2 points, significantly lower than the mean of 10.8 ± 8.0 previously reported by Ignatius and De La Garza II in a psychiatric oncology cohort (p < 0.001). There was no significant difference in demoralization scores across disease stages (p = 0.8). DS-II scores in univariable models were associated with depression (β = 0.79, p < 0.001), age (β = -0.09, p = 0.008), and women (p = 0.002).

conclusionDemoralization in this cohort of patients with PC was lower than that reported by Ignatius et al., although differences in recruitment settings and patient characteristics limit direct comparisons. Though disease stage did not impact demoralization scores in PC, our study found demoralization was strongly associated with concurrent depression, young age, and women. Understanding the risk factors associated with demoralization in PC can help enhance the quality of psychosocial care in oncology.

Indexed as

Adaptation, PsychologicalDemoralizationDepressionPancreatic NeoplasmsStress, PsychologicalAgedAged, 80 and overFemaleHumansMaleMiddle AgedRisk FactorsSurveys and Questionnairesdemoralizationdemoralization scale 2 (DS‐II)depressionpancreatic cancersociodemographic factors

Identifiers

PMID42714969
PMCPMC13557214

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.