Evidence map›Paper›PMID 42714715›Full record

ArticleMolecular biology reports2026

Acteoside alleviates high glucose-induced ROS accumulation and ferroptosis in ARPE-19 cells by activating the NRF2 signaling pathway.

Shuhong Shen, Qianbo Chen, Yan Li, Jia Ma, Yuxin Zhang, Huipeng Luo, Dan Peng, Xiaoting Xi

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Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Shuhong Shen *Ophthalmology Department, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Qianbo Chen *Ophthalmology Department, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Yan LiOphthalmology Department, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Jia MaOphthalmology Department, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Yuxin ZhangOphthalmology Department, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Huipeng LuoOphthalmology Department, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Dan PengOphthalmology Department, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Xiaoting XiOphthalmology Department, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China. xi_xiao_ting@163.com.

Funding

Major Science and Technology Special Project of Yunnan Province, Department of Science and Technology of Yunnan Province 202302AA310026National Natural Science Foundation of China 8236021, 82360210 and 82360206Special Project for the Selection of High-level Scientific and Technological Talents and Innovation Teams in Yunnan Province - Training Object Project for Technological Innovation Talents 202405AD350028"Xingdian Talents" Support Project of Yunnan Province RLMY20250011Yunnan Provincial Leader in Medical Disciplines D-2024051
6 · The paper itself

Abstract

objectiveThe role of Acteoside (ACT) in regulating ferroptosis of retinal pigment epithelial (RPE) cells in diabetic retinopathy (DR) through the NRF2 pathway was investigated.

methodsAn in vitro DR model was constructed by inducing ARPE-19 cells with 33 mmol/L high glucose (HG), and a C57BL/6 mouse DR model was established via intraperitoneal injection of STZ and treated with different doses of ACT. Ferroptosis was assessed using CCK-8 assay, kits, BODIPY-C11 staining, and Western blot. NRF2 nuclear translocation was examined by immunofluorescence. Retinal damage was evaluated by HE staining.

resultsCompared to the NG group, the HG group showed significantly reduced ARPE-19 cell viability, increased intracellular Fe

conclusionACT alleviated HG-induced ROS accumulation and ferroptosis in ARPE-19 cells by activating the NRF2 pathway, and ACT upregulated NRF2 and inhibited ferroptosis in the retina of DR mice, thereby ameliorating retinal injury.

Indexed as

Diabetic RetinopathyFerroptosisGlucoseGlucosidesNF-E2-Related Factor 2PhenolsReactive Oxygen SpeciesAnimalsCell LineCell SurvivalHumansLipid PeroxidationMaleMiceMice, Inbred C57BLOxidative StressacteosideGlucoseGlucosidesNFE2L2 protein, humanNfe2l2 protein, mouseNF-E2-Related Factor 2PhenolsPolyphenolsReactive Oxygen SpeciesActeosideDiabetic retinopathyFerroptosisNRF2RPE

Identifiers

PMID42714715

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