ArticleNeuroradiology2026
Multiparametric static hybrid ¹⁸F-FET PET/MR for preoperative prediction of TERT promoter mutation in glioblastoma.
Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposesTo determine whether multiparametric hybrid
methodsWe retrospectively included 220 patients with newly diagnosed glioblastoma at our institution between June 2021 and December 2025. Parametric maps, including ¹⁸F-FET PET, cerebral blood flow (CBF), and apparent diffusion coefficient (ADC), were co-registered with fluid-attenuated inversion recovery (FLAIR) images. Tumor volumes of interest (VOIs) were delineated on FLAIR and transferred to aligned maps for quantitative analysis. Contralateral normal white matter served as the reference region to calculate normalized ADC and CBF values (nADC and nCBF), defined as tumor-to-normal ratios, while PET uptake was expressed as a tumor-to-brain ratio (TBR). Independent predictors were identified using multivariable logistic regression. Diagnostic performance was evaluated using receiver operating characteristic (ROC) analysis with calculation of the area under the curve (AUC).
resultsIn multivariable logistic regression analysis, age (OR 1.088, 95% CI 1.030-1.148; P = 0.002), TBR
conclusionCombining age with multiparametric
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