ArticleJournal of the American Chemical Society2026
Guest-Induced Vibration Locking and Fluorescence Switching in a Pyrene-Functionalized Covalent Organic Framework (COF) for Perfluorooctanoic Acid (PFOA) Recognition.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
19 authors.
Funding
Abstract
Light-up luminescent covalent organic framework (COF) sensors hold promise for rapid and selective detection of molecular pollutants, yet their performance is often limited by insufficient guest-induced rigidity and incomplete mechanistic understanding. Here, we introduce a pyrene-functionalized flexible covalent organic framework (PY-TTA COF) that undergoes a guest-induced molecular-locking process upon exposure to perfluorooctanoic acid (PFOA), producing a pronounced fluorescence turn-on response in aqueous media. The pendent pyrene chromophores, which project into the pore interior, create an adaptable microenvironment in which PFOA binding, involving hydrogen-bonding interactions, possible proton-transfer processes at imine/pyridine nitrogen sites, and C-F···π interactions, restricts local molecular motions and enhances radiative emission. Solid-state NMR spectroscopy, supported by semiempirical calculations, provides molecular-level insight into the hydrogen-bonding and fluorine-aromatic proximities associated with this locking effect, while PXRD and TEM reveal guest-induced structural modulation while confirming preservation of framework crystallinity. This guest-locked luminescence enhancement enables fluorescence-based and recyclable detection of PFOA with a limit of detection of 2.7 μg L-1. The demonstrated mechanism establishes a design strategy for developing stimuli-responsive COFs with tunable photophysical properties and environmentally relevant sensing capabilities.
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