ArticleJournal of the American Chemical Society2026
Prebiotically Plausible Synthesis of N-Cyanoimidazole for Phosphate Activation and Templated RNA Ligation.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Phosphate activation is a key step in the transition from mononucleotides and short oligonucleotides to polynucleotides by primer-extension and/or ligation. Prebiotically plausible phosphate activating reagents have remained elusive, with potential candidates limited by either poor reactivity or uncertain prebiotic provenance. Here we report a prebiotically plausible synthesis of N-cyanoimidazole, a known and efficient phosphate activating reagent, by reaction of thiocyanogen with imidazole. We further demonstrate that N-cyanoimidazole can effect mononucleotide activation and highly efficient RNA ligation in nicked duplexes with a range of oligomers including trimers and dimers.
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