ArticleJournal of the American Chemical Society2026
Carbenylative Buchwald-Hartwig Coupling of Aryl Halides, N-Tosylhydrazones, and Anilines.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
A Pd/Cu cocatalyzed synthesis of N-benzhydryl amines from aryl halides (electrophiles), N-tosylhydrazones (carbene equivalents), and anilines (nucleophiles) has been developed. The reaction operates under mild conditions and exhibits broad substrate scope and excellent functional group tolerance. The synthetic utility of this approach is highlighted by the concise preparation of various drug molecules and their analogues, as well as its integration into downstream derivatizations. The essential role of Cu complexes is unusual for Pd-catalyzed C-N cross-coupling reactions, which usually do not require a cocatalyst for ligand exchange. We propose that this dual catalysis strategy is necessary to control the timing of Pd amido complex formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.