ArticleJournal of the American Heart Association2026
Study Protocol for a Randomized Controlled Trial Investigating Acute Cardiometabolic Responses to Heat-Ozone Coexposure and the Interventional Role of Omega-3 Eicosapentaenoic Acid: The HOEPA Study.
Junqi Li, Teng Wang, Jiarun Mi, Wenyi Liao, Lingya Xu, Zhiqin Wang, Yubei Zhang, Yan Tian, Yifan Xu, Xi Chen and 4 more
Abstract readClinical Trial Protocol
In one paragraphArticle in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Junqi LiSchool of Health Policy and Management Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.ORCID 0009-0003-1916-1832 Teng WangSchool of Health Policy and Management Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.ORCID 0000-0001-5323-5274 Jiarun MiSchool of Health Policy and Management Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.ORCID 0000-0001-6186-7132 Wenyi LiaoSchool of Health Policy and Management Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.ORCID 0009-0009-0519-2666 Lingya XuSchool of Health Policy and Management Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.
Zhiqin WangSchool of Health Policy and Management Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.ORCID 0009-0006-5180-000X Yubei ZhangSchool of Health Policy and Management Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.ORCID 0009-0007-5430-5159 Yan TianMEEKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health Peking University Beijing China.ORCID 0009-0007-9898-6195 Yifan XuMEEKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health Peking University Beijing China.ORCID 0000-0001-7899-4525 Xi ChenMEEKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health Peking University Beijing China.
Tianjia GuanSchool of Health Policy and Management Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.
Jicheng GongMEEKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health Peking University Beijing China.ORCID 0000-0002-8943-8804 Xinghua QiuMEEKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health Peking University Beijing China.ORCID 0000-0001-9874-8030 Tong ZhuMEEKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health Peking University Beijing China.ORCID 0000-0002-2752-7924 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundGlobal climate change is intensifying extreme heat events and may exacerbate ozone (O
methodsThe HOEPA (Cardiovascular Health Effects of Combined Exposure to High Temperature and Ozone and the Intervention Effects and Mechanisms of EPA Nutritional Supplementation) study will investigate whether omega-3 eicosapentaenoic acid (EPA) supplementation mitigates acute cardiometabolic impairments in response to heat-O
conclusionThis study design is intended to provide a rigorous experimental framework for elucidating acute cardiometabolic responses to combined heat and O REGISTRATION: URL: https://www.Chictr.org.cn; Unique Identifier: ChiCTR2500099752.
Indexed as
Cardiovascular DiseasesDietary SupplementsEicosapentaenoic AcidHot TemperatureOzoneAdultDouble-Blind MethodFemaleHumansMaleMiddle AgedOxidative StressRandomized Controlled Trials as TopicYoung AdultEicosapentaenoic AcidOzonecardiometabolic diseasesEPAheatnutritionozone
Identifiers
PMID42714408
PMCPMC13744960
What OpenQuestion holds
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