ArticleJournal of applied clinical medical physics2026
Quantitative Cherenkov-excited fluorescence emission dosimetry for HDR Co-60 brachytherapy: Calibration and planar validation against TPS.
Article in Journal of applied clinical medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Quantitative Cherenkov-excited fluorescence emission dosimetry for HDR Co-60 brachytherapy: Calibration and planar validation against TPS.Journal of applied clinical medical physics · 2026Article
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3 authors.
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Abstract
backgroundAccurate dose verification in High-Dose-Rate (HDR) brachytherapy presents a significant challenge due to steep dose gradients and the absence of beam collimation. Conventional quality assurance (QA) methods typically rely on point detectors or film-based techniques, which lack the capability to provide real-time, full-field visualization of dose distributions in a water-equivalent medium. While Cherenkov emission (CE) imaging has been investigated for Iridium-192 ( PURPOSE: This study aims to characterize the relationship between Cherenkov emission intensity and absorbed dose generated by an HDR
methodsA custom 3D-printed polylactic acid (PLA) phantom was fabricated with an internal cavity filled with an aqueous quinine hemisulfate solution (1 g/L). This solution was used to convert ultraviolet Cherenkov photons into isotropic visible fluorescence, thereby enhancing optical signal detection. Optical emissions were captured using a standard monochrome CMOS camera positioned at a 24 cm working distance. To eliminate radiation-induced artifacts on the sensor without relying on complex time-gated hardware, an image processing pipeline comprising dark frame subtraction, median filtering, and morphological operations was applied. A calibration function was established by delivering doses between 10 and 1500 cGy using a
resultsThe dosimetric calibration demonstrated a highly predictable and linear dose-response relationship, yielding a coefficient of determination (R
conclusionThe integration of Cherenkov-excited fluorescence imaging with a standard CMOS sensor provides a highly linear, practical, and cost-effective planar dose verification tool for continuous-emission
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