Evidence map›Paper›PMID 42714063›Full record

ArticleMediators of inflammation2026

Role of Prokineticin-2 and Cytokines in Synovial Fluid in Traumatic Anterior Cruciate Ligament Injuries.

Marco Crippa, Silvia Franchi, Laura Rizzi, Paola Sacerdote, Giulia Galimberti, Laura Antolini, Massimiliano Piatti, Nicola Portinaro, Giada Amodeo, Giovanni Zatti and 3 more

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In one paragraph

Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marco CrippaOrthopedic Department, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, Italy.
Silvia FranchiDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20129, Milan, Italy, unimi.it.
Laura RizziSchool of Medicine and Surgery, University of Milano-Bicocca, 20900, Monza, Italy, unimib.it.
Paola SacerdoteDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20129, Milan, Italy, unimi.it.ORCID https://orcid.org/0000-0003-4577-511X
Giulia GalimbertiDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20129, Milan, Italy, unimi.it.
Laura AntoliniBicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 Centre), School of Medicine and Surgery, University of Milano-Bicocca, 20900, Monza, Italy, unimib.it.
Massimiliano PiattiDepartment of Orthopedic Surgery, Policlinico San Pietro, 24036, Ponte San Pietro, Italy.
Nicola PortinaroDepartment of Pediatric Surgery, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122, Milan, Italy, policlinico.mi.it.
Giada AmodeoDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20129, Milan, Italy, unimi.it.
Giovanni ZattiOrthopedic Department, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, Italy.
Antonio TorselloSchool of Medicine and Surgery, University of Milano-Bicocca, 20900, Monza, Italy, unimib.it.
Marco TuratiOrthopedic Department, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, Italy.ORCID https://orcid.org/0000-0002-5208-3077
Marco BigoniSchool of Medicine and Surgery, University of Milano-Bicocca, 20900, Monza, Italy, unimib.it.

Funding

CRUI-CAREFondo di Ateneo per la Ricerca of the University of Milano-BicoccaUniversità degli Studi di Milano-Bicocca
6 · The paper itself

Abstract

backgroundAnterior cruciate ligament (ACL) tears induce a proinflammatory intra-articular environment. Despite successful ACL reconstruction (ACLR), post-traumatic osteoarthritis (PTOA) incidence remains high. The role of prokineticin-2 (PK2), a novel inflammatory and pain mediator, was investigated in this observational study of traumatic ACL injuries, associated with meniscal tears.

methodsTwenty patients with isolated ACL tears (ACL group) and 20 with associated meniscal injury (ACL + M group) were enrolled. Synovial fluid PK2, IL-10, and TNF-α levels were measured using ELISA method. Patients underwent long-term follow-up (minimum 5 years) with clinical reassessment using patient-reported outcome measures (PROMs) (IKDC, Lysholm, Tegner activity scale, SKV).

resultsPK2 was detected in both ACL and ACL + M groups without significant differences. Higher PK2 levels were associated with hemarthrosis and correlated positively with IL-10. No associations were found between PK2 levels and demographic factors or time from injury. At follow-up, PK2 negatively correlated with IKDC, Lysholm, and SKV scores.

conclusionThis study provides initial evidence of PK2 in synovial fluid following ACL injury, suggesting its potential role in knee inflammation. PK2 may represent a candidate biomarker involved in the post-traumatic inflammatory microenvironment; however, further longitudinal studies including structural outcomes are needed.

Indexed as

Anterior Cruciate Ligament InjuriesCytokinesGastrointestinal HormonesNeuropeptidesSynovial FluidAdolescentAdultEnzyme-Linked Immunosorbent AssayFemaleHumansInterleukin-10MaleTumor Necrosis Factor-alphaYoung AdultCytokinesGastrointestinal HormonesInterleukin-10NeuropeptidesPROK2 protein, humanTumor Necrosis Factor-alphaanterior cruciate ligament tearcytokinesmeniscal injurypost-traumatic osteoarthritisprokineticin-2synovial fluid

Identifiers

PMID42714063
PMCPMC13556303

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.