ArticleJournal of diabetes research2026
High Serum Polyunsaturated Fatty Acids for the Increased Risk of Gestational Diabetes Mellitus Through LPC Pathways: A Prospective Nested Case-Control Study in China.
Article in Journal of diabetes research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
aimsThe study aimed to investigate the following: (1) whether early-pregnancy serum polyunsaturated fatty acid (PUFA) species are associated with the risk of gestational diabetes mellitus (GDM); and (2) whether lysophosphatidylcholine (LPC)18:0 may statistically explain these associations in Chinese pregnant women. MATERIALS AND
methodsWe conducted a 1:1 age-matched case-control study of 486 pregnant women nested within a prospective cohort in Tianjin, China. Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression analysis was used to identify the PUFA species independently associated with GDM. Conditional logistic regression was conducted to obtain odds ratios (ORs) and their 95% confidence intervals (CIs). Sobel mediation analysis was used to assess the potential statistical role of LPC18:0.
resultsAmong five PUFA species that differed significantly between cases and controls, arachidonic acid (AA, 20:4) and docosahexaenoic acid (DHA, 22:6) were selected and further analyzed. High AA (≥ 3.63 nmol/mL) and DHA (≥ 0.59 nmol/mL) were associated with increased GDM risk, with multivariable-adjusted ORs of 2.89 (95% CI: 1.84-4.54) and 2.90 (95% CI: 1.82-4.63), respectively. These associations were stronger among women with pre-pregnancy overweight/obesity (AA, OR: 5.32, 95% CI: 2.48-11.42; DHA, OR: 3.39, 95% CI: 1.65-6.99). Further adjustment for high LPC18:0 substantially attenuated the associations of AA (OR: 0.90, 95% CI: 0.45-1.80) and DHA (OR: 0.97, 95% CI: 0.51-1.85) with GDM risk, with Sobel test p values < 0.0001.
conclusionsHigher serum AA and DHA levels in early pregnancy were associated with increased GDM risk. LPC18:0 may statistically explain part of these observed associations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.