ArticleJournal of the Pediatric Infectious Diseases Society2026
Pharmacokinetics of Clofazimine Tablet Formulation in Children with Rifampicin-Resistant Tuberculosis in CATALYST, a Multi-Site International Trial.
Yuanxi Zou, Megan Palmer, Melchor V G Frias, Dessa J O Casalme, Aarti A Kinikar, Mandar Paradkar, Vandana Kulkarni, Pragathi Kamath, Ingrid Courtney, Heather Draper and 7 more
Abstract readMulticenter Study
In one paragraphArticle in Journal of the Pediatric Infectious Diseases Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
17 authors.
Megan PalmerDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0002-2534-2483 Melchor V G FriasResearch Department, De La Salle Medical and Health Sciences Institute, Dasmariñas, The Philippines.
Dessa J O CasalmeResearch Department, De La Salle Medical and Health Sciences Institute, Dasmariñas, The Philippines.
Mandar ParadkarBJ Government Medical College-Johns Hopkins University Clinical Research Site, Pune, India.ORCID 0000-0001-9843-4656 Vandana KulkarniBJ Government Medical College-Johns Hopkins University Clinical Research Site, Pune, India.ORCID 0000-0002-3488-2692 Pragathi KamathBJ Government Medical College, Pune, India.
Ingrid CourtneyDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Heather DraperDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Lubbe WiesnerDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-9070-8699 Paolo DentiDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-7494-079X Louvina van der LaanDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0002-3584-7477 Anthony J Garcia-PratsDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0002-9280-1950 Anneke C HesselingDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0001-9399-9834 Funding
National Academic Infrastructure for Supercomputing in Sweden (NAISS) at Uppsala Multi-Disciplinary Center for Advanced Computational Science (UPPMAX) NAISS 2023/22-1058Swedish Research Council 2022-06725
6 · The paper itselfAbstract
We evaluated the pharmacokinetics of a novel child-friendly 50 mg clofazimine tablet formulation that disperses quickly in water, compared to traditional gel capsules, in 36 children routinely treated for rifampicin-resistant tuberculosis. No substantial pharmacokinetic difference was observed between tablets and gel capsules, supporting the tablet formulation use for paediatric dosing.
Indexed as
Antitubercular AgentsClofazimineTuberculosis, Multidrug-ResistantAdolescentChildChild, PreschoolFemaleHumansMaleRifampinTabletsAntitubercular AgentsClofazimineRifampinTabletschild-friendly formulationclofaziminepaediatricpopulation pharmacokineticstuberculosis
Identifiers
PMID42713890
PMCPMC13623529
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